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公开(公告)号：US20230029341A1
公开(公告)日：2023-01-26
申请号：US17757056
申请日：2020-12-11
IPC分类号： C07K14/705 , C07K14/725 , C07K16/28 , A61P35/00
摘要： Provided are polynucleotides comprising nucleic acid sequences encoding chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are vectors and immune cells comprising said polynucleotides.
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公开(公告)号：US12037377B2
公开(公告)日：2024-07-16
申请号：US17663148
申请日：2022-05-12
IPC分类号： C07K14/705 , A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/28 , C07K16/30
CPC分类号： C07K14/70503 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C07K16/2833 , C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/03
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
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公开(公告)号：US20220289818A1
公开(公告)日：2022-09-15
申请号：US17663148
申请日：2022-05-12
IPC分类号： C07K14/705 , A61K35/17 , C07K16/30
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
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公开(公告)号：US11254726B2
公开(公告)日：2022-02-22
申请号：US17230637
申请日：2021-04-14
IPC分类号： C07K14/705 , A61K35/17 , C07K16/30
摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.
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