公开(公告)号：US20230029341A1

公开(公告)日：2023-01-26

申请号：US17757056

申请日：2020-12-11

申请人： A2 Biotherapeutics, Inc.

发明人： Carl Alexander Kamb ,  Agnes E. Hamburger ,  Breanna Diandreth ,  Mark E. Daris ,  Kiran Deshmukh

IPC分类号： C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61P35/00

摘要： Provided are polynucleotides comprising nucleic acid sequences encoding chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are vectors and immune cells comprising said polynucleotides.

公开(公告)号：US12037377B2

公开(公告)日：2024-07-16

申请号：US17663148

申请日：2022-05-12

申请人： A2 Biotherapeutics, Inc.

发明人： Carl Alexander Kamb ,  Agnes E. Hamburger ,  Breanna Diandreth ,  Mark E. Daris ,  Kiran Deshmukh

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30

CPC分类号： C07K14/70503 ,  A61K35/17 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70578 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/3069 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/03

摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.

公开(公告)号：US20240000938A1

公开(公告)日：2024-01-04

申请号：US18253721

申请日：2021-11-23

申请人： A2 Biotherapeutics, Inc.

发明人： Carl Alexander Kamb ,  Agnes Hamburger ,  Breanna Diandreth ,  Han Xu ,  Julyun Oh

IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/32 ,  C07K16/30 ,  A61K45/06 ,  A61P35/00 ,  C12N15/86 ,  C12N15/11 ,  C12N9/22

CPC分类号： A61K39/4632 ,  C07K14/70503 ,  C07K14/7051 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/3007 ,  C07K16/2803 ,  A61K45/06 ,  A61K39/4611 ,  A61K39/4612 ,  A61K39/4613 ,  A61K39/464482 ,  A61K39/464468 ,  A61K39/464404 ,  A61P35/00 ,  C12N15/86 ,  C12N15/111 ,  C12N9/22 ,  C07K2319/03 ,  A61K2239/21 ,  A61K2239/22 ,  A61K2239/13 ,  C12N2310/20 ,  C12N2740/15043

摘要： The disclosure relates to immune cells comprising systems of two engineered receptors each having a ligand binding domain, collectively designed to target cells identified by loss of heterozygosity and used to treat a disease or disorder, for example, cancer. The disclosure provides immune cells expressing two engineered receptors, methods of making same, and polynucleotides and vectors encoding same.

公开(公告)号：US20220289818A1

公开(公告)日：2022-09-15

申请号：US17663148

申请日：2022-05-12

申请人： A2 Biotherapeutics, Inc.

发明人： Carl Alexander Kamb ,  Agnes E. Hamburger ,  Breanna Diandreth ,  Mark E. Daris ,  Kiran Deshmukh

IPC分类号： C07K14/705 ,  A61K35/17 ,  C07K16/30

摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.

公开(公告)号：US11254726B2

公开(公告)日：2022-02-22

申请号：US17230637

申请日：2021-04-14

申请人： A2 Biotherapeutics, Inc.

发明人： Carl Alexander Kamb ,  Agnes E. Hamburger ,  Breanna Diandreth ,  Mark E. Daris ,  Kiran Deshmukh

IPC分类号： C07K14/705 ,  A61K35/17 ,  C07K16/30

摘要： Provided are chimeric antigen receptors having the hinge, transmembrane region, and/or intracellular domain of LILRB1, or functional fragments or variants thereof. Also provided herein are cells comprising the LILRB1 based receptors, and methods of making and using same.