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公开(公告)号：US09834581B2
公开(公告)日：2017-12-05
申请号：US14433578
申请日：2013-10-04
申请人： AADIGEN, LLC
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , A61K31/337 , A61K31/704 , A61K47/48 , A61K47/10
CPC分类号： C07K7/06 , A61K31/337 , A61K31/704 , A61K47/10 , A61K47/64 , A61K47/6929 , C07K7/08 , C07K14/001
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A or S; X in positions 3, 9 and 10 are, independently from each other, W or F; X in position 6 is R if X in position 8 is S, and X in position 6 is S if X in position 8 is R; X in position 7 is L or none; X in position 11 is R or none, and wherein X in position 7 is L if X in position 11 is none.
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公开(公告)号：US10421784B2
公开(公告)日：2019-09-24
申请号：US15463994
申请日：2017-03-20
申请人： AADIGEN, LLC
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence: X1X2X3WWX4X5WAX6X3X7X8X9X10X11X12WX13R (SEQ ID No: 10), wherein X1, is beta-A or S, X2 is L or none, X3 is R or none, X4 is L, R or G, X5 is R, W or S, X6 is S, P or T, X7 is W or P, X8 is F, A or R, X9 is S, L, P or R, X10 is R or S, X11 n is W or none, X12 is A, R or none and X13 is W or F, and wherein if X3 is none, then X3, X11 and X12 are none as well.
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公开(公告)号：US10287581B2
公开(公告)日：2019-05-14
申请号：US15160939
申请日：2016-05-20
申请人： AADIGEN, LLC
IPC分类号： C07K7/08 , A61K47/54 , A61K47/60 , A61K47/64 , A61K47/69 , C12N15/11 , A61K31/337 , A61K31/409 , A61K31/704 , A61K31/713 , C12N15/113 , A61K31/7072 , A61K31/7105
摘要： The present invention relates to a new family of cell-penetrating peptides, comprising an amino acid sequence X1LX2RALWRLX3RX4LWRLX5X6X7X8, wherein X1 is beta-A or S, X2 is F or W, X3 is L, W, C or I, X4 is S, A, N or T, X5 is L or W, X6 is W or R, X7 is K or R, and X8 is A or none. These peptides exhibit high efficiency, low toxicity and a natural tropism for lung tissues, and can be used either in simple complex with the cargo to be vectorised, or in nanoparticles comprising two layers of cell-penetrating peptides around the cargo.
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公开(公告)号：US10688194B2
公开(公告)日：2020-06-23
申请号：US16171767
申请日：2018-10-26
申请人： AADIGEN, LLC
IPC分类号： A61K47/42 , A61K47/62 , A61K47/64 , C07K7/08 , A61K9/00 , A61K49/00 , A61K9/51 , A61K31/704 , A61K31/7088 , A61K38/02 , A61K39/395 , A61K47/60
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
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公开(公告)号：US10118944B2
公开(公告)日：2018-11-06
申请号：US14433592
申请日：2013-10-04
申请人： AADIGEN, LLC
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of a beta-alanine or a serine in N-terminal position, linked to a sequence consisting of 9 consecutive amino acids from the sequence RXWXRLWXRLR (SEQ ID NO:7), wherein X in position 2 is R or S and X in positions 4 and 8 are, independently from each other, W or F.
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公开(公告)号：US09579395B2
公开(公告)日：2017-02-28
申请号：US14433570
申请日：2013-10-04
申请人： AADIGEN LLC
IPC分类号： A61K47/42 , C07K7/08 , A61K47/48 , A61K9/00 , A61K49/00 , A61K9/51 , A61K31/704 , A61K31/7088 , A61K38/02 , A61K39/395
CPC分类号： A61K47/64 , A61K9/0019 , A61K9/5169 , A61K9/5192 , A61K31/704 , A61K31/7088 , A61K38/02 , A61K39/395 , A61K47/42 , A61K47/60 , A61K47/645 , A61K47/6455 , A61K49/0056 , A61K49/0093 , C07K7/08
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
摘要翻译： 一种细胞穿透肽，其特征在于其包含氨基酸序列X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13（SEQ ID No：11），其中X1为F或W，X2为F，W或Y，X3为β-A或S，X4为K， R或L，X5为E，R或S，X6为R.T或S，X7为E，R或S，X8为无，F或W，X9为P或R，X10为R或L，X11为 K，W或R，X 12为R或F，X 13为R或K.
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公开(公告)号：US11713336B2
公开(公告)日：2023-08-01
申请号：US16930091
申请日：2020-07-15
申请人： AADIGEN, LLC
发明人： Gilles Divita , Neil Desai
IPC分类号： C07K7/08 , C12N15/87 , A61K47/69 , A61K47/64 , A61K31/713 , C12N15/113 , A61K38/00
CPC分类号： C07K7/08 , A61K31/713 , A61K47/64 , A61K47/6929 , C12N15/113 , C12N15/1137 , C12N15/87 , A61K38/00 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2320/32
摘要： The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
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公开(公告)号：US10745440B2
公开(公告)日：2020-08-18
申请号：US15539619
申请日：2015-12-23
申请人： AADIGEN, LLC
发明人： Gilles Divita , Neil Desai
IPC分类号： C07K7/08 , C12N15/87 , A61K47/69 , A61K47/64 , A61K31/713 , C12N15/113 , A61K38/00
摘要： The present invention pertains to peptides and peptide-containing complexes/nanoparticles that are useful for stabilizing and delivering cargo molecules such as nucleic acids.
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公开(公告)号：US10189876B2
公开(公告)日：2019-01-29
申请号：US15802402
申请日：2017-11-02
申请人： AADIGEN, LLC
IPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , A61K31/337 , A61K31/704 , A61K47/64 , A61K47/69 , A61K47/10
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is beta-A or S; X in positions 3, 9 and 10 are, independently from each other, W or F; X in position 6 is R if X in position 8 is S, and X in position 6 is S if X in position 8 is R; X in position 7 is L or none; X in position 11 is R or none, and wherein X in position 7 is L if X in position 11 is none.
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公开(公告)号：US10111965B2
公开(公告)日：2018-10-30
申请号：US15428864
申请日：2017-02-09
申请人： AADIGEN LLC
IPC分类号： A61K47/42 , A61K47/62 , A61K47/64 , A61K9/00 , A61K49/00 , A61K9/51 , A61K31/704 , A61K31/7088 , A61K39/395 , A61K38/02 , C07K7/08 , A61K47/60
摘要： A cell-penetrating peptide characterized in that it comprises an amino acid sequence X3X4X1X2X5X4X1X2X6X7X1X8X9X10X11X12X13 (SEQ ID No: 11), wherein X1 is F or W, X2 is F, W or Y, X3 is beta-A or S, X4 is K, R or L, X5 is E, R or S, X6 is R. T or S, X7 is E, R or S, X8 is none, F or W, X9 is P or R, X10 is R or L, X11 is K, W or R, X12 is R or F and X13 is R or K.
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