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公开(公告)号：US20240174731A1
公开(公告)日：2024-05-30
申请号：US18352769
申请日：2023-07-14
Applicant: AbbVie Inc. , Apogenix AG
Inventor： Fritz G. Buchanan , Christian Gieffers , Oliver Hill , Susan E. Lappe , Darren C. Phillips , Meinholf Thiemann
IPC: C07K14/705 , A61K38/00
CPC classification number: C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：US20180222962A1
公开(公告)日：2018-08-09
申请号：US15887509
申请日：2018-02-02
Applicant: AbbVie Inc. , Apogenix AG
Inventor： Fritz G. Buchanan , Christian Gieffers , Oliver Hill , Susan E. Lappe , Darren C. Phillips , Meinholf Thiemann
IPC: C07K14/705
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：US20150337042A1
公开(公告)日：2015-11-26
申请号：US14664453
申请日：2015-03-20
Applicant: ABBVIE INC.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Fritz G. Buchanan , Jonathan A. Meulbroek , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Abstract translation: 本发明涉及抗表皮生长因子（EGFR）抗体和抗体药物偶联物（ADC），包括使用所述抗体和ADC的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US20150337027A1
公开(公告)日：2015-11-26
申请号：US14694358
申请日：2015-04-23
Applicant: AbbVie Inc. , Apogenix GMBH
Inventor： Oliver Hill , Christian Gieffers , Meinolf Thiemann , Fritz G. Buchanan , Darren C. Phillips , Susan E. Lappe
IPC: C07K14/705
CPC classification number: C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Abstract translation: 本文提供了特异性TRAIL受体激动剂蛋白，编码它们的核酸，以及治疗具有TRAIL相关疾病或病症的受试者的方法。 本文提供的TRAIL受体激动剂蛋白质包含三个可溶性TRAIL结构域和Fc片段。 TRAIL受体激动剂蛋白质基本上非聚集并且适用于治疗，诊断和/或研究应用。
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公开(公告)号：US20250145688A1
公开(公告)日：2025-05-08
申请号：US18892964
申请日：2024-09-23
Applicant: AbbVie Inc. , Apogenix AG
Inventor： Fritz G. Buchanan , Christian Gieffers , Oliver Hill , Susan E. Lappe , Darren C. Phillips , Meinolf Thiemann
IPC: C07K14/705 , A61K38/00
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：US20210040178A1
公开(公告)日：2021-02-11
申请号：US16993569
申请日：2020-08-14
Applicant: AbbVie Inc. , Apogenix AG
Inventor： Fritz G. Buchanan , Christian Gieffers , Oliver Hill , Susan E. Lappe , Darren C. Phillips , Meinholf Thiemann
IPC: C07K14/705
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：US09908927B2
公开(公告)日：2018-03-06
申请号：US14694358
申请日：2015-04-23
Applicant: AbbVie Inc. , Apogenix AG
Inventor： Oliver Hill , Christian Gieffers , Meinolf Thiemann , Fritz G. Buchanan , Darren C. Phillips , Susan E. Lappe
CPC classification number: C07K14/70575 , A61K38/00 , C07K2319/00 , C07K2319/30
Abstract: Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
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公开(公告)号：US20170072065A1
公开(公告)日：2017-03-16
申请号：US15349692
申请日：2016-11-11
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Fritz G. Buchanan , Jonathan A. Meulbroek , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Abstract translation: 本发明涉及抗表皮生长因子（EGFR）抗体和抗体药物偶联物（ADC），包括使用所述抗体和ADC的组合物和方法。
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