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公开(公告)号：US20170072065A1
公开(公告)日：2017-03-16
申请号：US15349692
申请日：2016-11-11
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Fritz G. Buchanan , Jonathan A. Meulbroek , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Abstract translation: 本发明涉及抗表皮生长因子（EGFR）抗体和抗体药物偶联物（ADC），包括使用所述抗体和ADC的组合物和方法。
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公开(公告)号：US10098968B2
公开(公告)日：2018-10-16
申请号：US15808419
申请日：2017-11-09
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US09915665B2
公开(公告)日：2018-03-13
申请号：US14141498
申请日：2013-12-27
Applicant: AbbVie, Inc.
Inventor： Lorenzo Benatuil , Jennifer Perez , Chung-Ming Hsieh
IPC: G01N33/68 , C40B20/04 , C40B30/04 , C07K16/46 , C12N15/10 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24
CPC classification number: G01N33/6854 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/244 , C07K16/245 , C07K16/468 , C07K2317/64 , C07K2317/92 , C12N15/1037 , C40B20/04 , C40B30/04
Abstract: System and methods are disclosed for identifying and isolating antibodies with specific affinity with an antigen of interest. Multiple DNA libraries encoding antibodies or their fragments are designed such that the encoded antibodies from different libraries are tagged differently. These libraries may be transformed into yeast cells. The variants of the antibodies are displayed on the surface of the yeast cells and flow cytometry may be used to sort the cells based on antigen affinity and the different tags on the antibodies. By allowing multiple libraries to be screened simultaneously, the disclosed methods help improve the efficiency of affinity.
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公开(公告)号：US09827330B2
公开(公告)日：2017-11-28
申请号：US15349692
申请日：2016-11-11
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20190134216A1
公开(公告)日：2019-05-09
申请号：US16154229
申请日：2018-10-08
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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Patent Agency Ranking
公开(公告)号：US20150337042A1
公开(公告)日：2015-11-26
申请号：US14664453
申请日：2015-03-20
Applicant: ABBVIE INC.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Fritz G. Buchanan , Jonathan A. Meulbroek , Chung-Ming Hsieh , Jennifer Perez
CPC classification number: A61K47/6811 , A61K47/6803 , A61K47/6847 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6863 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K14/00 , C07K16/2863 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Abstract translation: 本发明涉及抗表皮生长因子（EGFR）抗体和抗体药物偶联物（ADC），包括使用所述抗体和ADC的组合物和方法。
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公开(公告)号：US20140170152A1
公开(公告)日：2014-06-19
申请号：US14073479
申请日：2013-11-06
Applicant: Abbvie Inc.
Inventor： Chung-ming Hsieh , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Jennifer Perez , Suju Zhong , Carrie Goodreau , Anca Clabbers
IPC: C07K16/24 , A61K45/06 , A61K39/395
CPC classification number: C07K16/241 , A61K39/3955 , A61K45/06 , A61K47/6847 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , G01N33/6863
Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
Abstract translation: 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20250163159A1
公开(公告)日：2025-05-22
申请号：US18670261
申请日：2024-05-21
Applicant: AbbVie Inc.
Inventor： Edward B. Reilly , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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公开(公告)号：US20140079705A1
公开(公告)日：2014-03-20
申请号：US14082502
申请日：2013-11-18
Applicant: Abbvie Inc.
Inventor： Chung-ming Hsieh , Jennifer Perez , Lorenzo Benatuil , Yuliya Kutskova , John Memmott , Suju Zhong , Lucia Eaton , Margaret Hugunin , Alyssa Brito , Anca Clabbers
CPC classification number: A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/241 , C07K16/244 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/5308
Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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公开(公告)号：US20220288221A1
公开(公告)日：2022-09-15
申请号：US17451622
申请日：2021-10-20
Applicant: AbbVie Inc.
Inventor： Edward B. REILLY , Andrew C. Phillips , Lorenzo Benatuil , Chung-Ming Hsieh , Jennifer Perez
Abstract: The invention relates to anti-epidermal growth factor (EGFR) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
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