公开(公告)号：US20190046668A1

公开(公告)日：2019-02-14

申请号：US15999117

申请日：2017-02-17

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A Grice ,  Todd K Jones ,  Justin S Cisar ,  Iain Peter Fraser

IPC: A61K51/04 ,  C07D295/205 ,  C12N9/20 ,  A61B6/03

CPC classification number: A61K51/0459 ,  A61B6/037 ,  C07B59/002 ,  C07B2200/05 ,  C07D295/205 ,  C12N9/20 ,  C12Y301/01023

Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.