公开(公告)号：US20240101687A1

公开(公告)日：2024-03-28

申请号：US18480071

申请日：2023-10-03

Applicant: ABL Bio Inc.

Inventor： Jinhyung AHN ,  Sungwon AN ,  Dongin KIM ,  Eunsil SUNG ,  Jaehyun EOM ,  Sang Hoon Lee ,  Weonkyoo YOU ,  Juhee KIM ,  Kyungjin PARK ,  Hyejin CHUNG ,  Jinwon JUNG ,  Bora LEE ,  Byungje SUNG ,  Yeunju KIM ,  Yong-Gyu SON ,  Seawon AHN ,  Daehae SONG ,  Jiseon YOO ,  Youngdon PAK ,  Donghoon YEOM ,  Yoseob LEE ,  Jaeho JUNG

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/18

CPC classification number: C07K16/2863 ,  A61K47/6845 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/567

Abstract: The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20230357412A1

公开(公告)日：2023-11-09

申请号：US18063550

申请日：2022-12-08

Applicant: ABL BIO INC.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Juhee KIM ,  Kyungjin PARK ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: A61P25/28 ,  C07K16/18 ,  C07K16/28

CPC classification number: C07K16/2863 ,  A61P25/28 ,  C07K16/18 ,  A61K2039/505

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20220125944A1

公开(公告)日：2022-04-28

申请号：US17436647

申请日：2020-03-06

Applicant: ABL BIO, INC.

Inventor： Jinwon JUNG ,  Juhee KIM ,  Youngdon Pak ,  Daehae SONG ,  Donghoon YEOM ,  Jaehyun EOM ,  Youngeun HONG ,  Bora LEE

IPC: A61K47/68 ,  C07H15/26 ,  A61K47/54

Abstract: The present invention relates to a novel compound comprising a galactose trigger moiety and cyclopropabenzindole (CBI), and an antibody-drug conjugate prepared by using same.

公开(公告)号：US20220348665A1

公开(公告)日：2022-11-03

申请号：US17616799

申请日：2020-06-15

Applicant: ABL Bio Inc.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Kyungjin PARK ,  Juhee KIM ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: C07K16/28 ,  C07K16/18 ,  A61P25/28

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20230279085A1

公开(公告)日：2023-09-07

申请号：US16759937

申请日：2018-11-16

Applicant: ABL Bio Inc.

Inventor： Sang Hoon LEE ,  Weonkyoo YOU ,  Jinhyung AHN ,  Sungwon AN ,  Jinwon JUNG ,  Bora LEE ,  Dongin KIM ,  Byungje SUNG ,  Yonggyu SON ,  Yeunju KIM ,  Jaehyun EOM ,  Seawon AHN ,  Youngdon PAK ,  Donghoon YEOM ,  Daehae SONG

IPC: C07K16/18 ,  G01N33/68 ,  A61P25/28

CPC classification number: C07K16/18 ,  G01N33/6896 ,  A61P25/28 ,  C07K2317/565 ,  C07K2317/567 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.

公开(公告)号：US20210284749A1

公开(公告)日：2021-09-16

申请号：US17053256

申请日：2019-06-26

Applicant: ABL BIO INC.

Inventor： Kyungjin PARK ,  Hyejin CHUNG ,  Kyeongsu PARK ,  Yangsoon LEE ,  Mikyung CHANG ,  Jaehyoung JEON ,  Youngkwang KIM ,  Junhyun JEONG ,  Jiseon YOO ,  Yeunju KIM ,  Donghoon YEOM ,  Eunjung KIM ,  Bora LEE ,  Jinwon JUNG

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.