公开(公告)号：US12049493B2

公开(公告)日：2024-07-30

申请号：US16475853

申请日：2018-01-05

Applicant: ABL Bio Inc.

Inventor： Jinhyung Ahn ,  Sungwon An ,  Dongin Kim ,  Eunsil Sung ,  Jaehyun Eom ,  Sang Hoon Lee ,  Seung-Jae Lee ,  Tae Kyung Kim ,  Min Sun Choi ,  Weonkyoo You ,  Jaeho Jung ,  Juhee Kim ,  Jinwon Jung ,  Yeunju Kim ,  Yonggyu Son ,  Byungje Sung

IPC: C07K16/18 ,  A61K39/00 ,  A61P25/14 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61P25/14 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N2800/2835

Abstract: The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.