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公开(公告)号：US20230405139A1
公开(公告)日：2023-12-21
申请号：US18209299
申请日：2023-06-13
发明人： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC分类号： A61K47/6849 , A61P35/00 , A61K47/6803 , C07K16/2803
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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公开(公告)号：US12049493B2
公开(公告)日：2024-07-30
申请号：US16475853
申请日：2018-01-05
申请人： ABL Bio Inc.
发明人： Jinhyung Ahn , Sungwon An , Dongin Kim , Eunsil Sung , Jaehyun Eom , Sang Hoon Lee , Seung-Jae Lee , Tae Kyung Kim , Min Sun Choi , Weonkyoo You , Jaeho Jung , Juhee Kim , Jinwon Jung , Yeunju Kim , Yonggyu Son , Byungje Sung
CPC分类号： C07K16/18 , A61P25/14 , G01N33/6896 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N2800/2835
摘要： The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.
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公开(公告)号：US20210024638A1
公开(公告)日：2021-01-28
申请号：US16939472
申请日：2020-07-27
申请人： ABL Bio Inc. , YUHAN CORPORATION
发明人： Yeryoung Yong , Ui-Jung Jung , Hyejin Chung , Kyeongsu Park , Wonjun Son , Yangsoon Lee , Yeunju Kim , Eunsil Sung , Youngkwang Kim , Youngdon Pak , Minji Park , Jaehyun Eom , Hyoju Choi , Moo Young Song , Na Rae Lee , Young Bong Park , Eun-Jung Lee , Eun-Jung Lee
摘要： Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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4.发明授权公开(公告)号：US12071483B1
公开(公告)日：2024-08-27
申请号：US16770728
申请日：2018-12-14
申请人： ABL Bio Inc.
发明人： Jinhyung Ahn , Sungwon An , Dongin Kim , Eunsil Sung , Jaehyun Eom , Sang Hoon Lee , Weonkyoo You , Juhee Kim , Kyungjin Park , Hyejin Chung , Jinwon Jung , Bora Lee , Byungje Sung , Yeunju Kim , Yong-Gyu Son , Seawon Ahn , Daehae Song , Jiseon Yoo , Youngdon Pak , Donghoon Yeom , Yoseob Lee , Jaeho Jung
IPC分类号： A61K39/395 , A61K47/68 , C07K16/18 , C07K16/28
CPC分类号： C07K16/2863 , A61K47/6845 , C07K16/18 , C07K2317/31 , C07K2317/565 , C07K2317/567
摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：US11707533B2
公开(公告)日：2023-07-25
申请号：US16940326
申请日：2020-07-27
发明人： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-Na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC分类号： A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/2803
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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