公开(公告)号：US20210024638A1

公开(公告)日：2021-01-28

申请号：US16939472

申请日：2020-07-27

申请人： ABL Bio Inc. ,  YUHAN CORPORATION

发明人： Yeryoung Yong ,  Ui-Jung Jung ,  Hyejin Chung ,  Kyeongsu Park ,  Wonjun Son ,  Yangsoon Lee ,  Yeunju Kim ,  Eunsil Sung ,  Youngkwang Kim ,  Youngdon Pak ,  Minji Park ,  Jaehyun Eom ,  Hyoju Choi ,  Moo Young Song ,  Na Rae Lee ,  Young Bong Park ,  Eun-Jung Lee ,  Eun-Jung Lee

IPC分类号： C07K16/28 ,  A61P35/00

摘要： Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US12071483B1

公开(公告)日：2024-08-27

申请号：US16770728

申请日：2018-12-14

申请人： ABL Bio Inc.

发明人： Jinhyung Ahn ,  Sungwon An ,  Dongin Kim ,  Eunsil Sung ,  Jaehyun Eom ,  Sang Hoon Lee ,  Weonkyoo You ,  Juhee Kim ,  Kyungjin Park ,  Hyejin Chung ,  Jinwon Jung ,  Bora Lee ,  Byungje Sung ,  Yeunju Kim ,  Yong-Gyu Son ,  Seawon Ahn ,  Daehae Song ,  Jiseon Yoo ,  Youngdon Pak ,  Donghoon Yeom ,  Yoseob Lee ,  Jaeho Jung

IPC分类号： A61K39/395 ,  A61K47/68 ,  C07K16/18 ,  C07K16/28

CPC分类号： C07K16/2863 ,  A61K47/6845 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/567

摘要： The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.

公开(公告)号：US12122830B1

公开(公告)日：2024-10-22

申请号：US17057646

申请日：2019-05-23

申请人： ABL Bio Inc.

发明人： Yangsoon Lee ,  Juhee Kim ,  Kyungjin Park ,  Donghoon Yeom ,  Kyeongsu Park ,  Hyejin Chung ,  Yeunju Kim ,  Eunyoung Park ,  Ui-Jung Jung ,  Eunsil Sung ,  Jinhyung Ahn ,  Byungje Sung ,  Daehae Song ,  Youngdon Pak

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/2803 ,  A61P35/00 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  G01N2333/705 ,  G01N2333/912

摘要： The present invention discloses an anti-ROR1 antibody specifically recognizing human and mouse ROR1. The monoclonal antibody can be usefully used for cancer targeting treatment including detection of various cancer expressing ROR1 through specific binding, and drug delivery to specific cancer, etc. as well as a cancer therapeutic agent, by inhibiting tumors.

公开(公告)号：US11891445B1

公开(公告)日：2024-02-06

申请号：US17057643

申请日：2019-05-24

申请人： ABL Bio Inc.

发明人： Kyeongsu Park ,  Yangsoon Lee ,  Hyejin Chung ,  Uijung Jung ,  Yong-Gyu Son ,  Sang-Jun Ha ,  Myeong Joon Kim ,  Eunyoung Park ,  Kyungjin Park ,  Eunsil Sung ,  Yeunju Kim ,  Jinhyung Ahn ,  Byungje Sung ,  Daehae Song ,  Youngdon Pak

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K16/2827 ,  A61P35/00 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70532

摘要： Provided is an anti-B7-H3 antibody specifically recognizing a B7-H3, which can be usefully as a cancer therapeutic agent, as having an inhibitory activity of an immune checkpoint which induces antibody-dependent cell-mediated cytotoxicity and T cell activation inhibited by B7-H3. In particular, the antibody having the inhibitory activity of an immune checkpoint can be used in combination with other immunoantibody therapeutic agents. In addition, it can be usefully used for cancer targeting treatment including detection of various cancers expressing B7-H3 through specific binding to B7-H3, and drug delivery to specific cancer, etc.