公开(公告)号：US09981030B2

公开(公告)日：2018-05-29

申请号：US14392333

申请日：2014-06-27

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Chia-Hung Wang ,  Shiou-Ting Li

IPC: A61K31/715 ,  C08B37/00 ,  A61K39/095 ,  C07H1/00 ,  C07H15/04 ,  C07H15/18 ,  A61K39/385 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K31/715 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/6037 ,  A61K2039/627 ,  C07H1/00 ,  C07H15/04 ,  C07H15/18 ,  C08B37/006

Abstract: Described herein are synthetic glycan conjugates comprising a carrier and a glycan moiety derived from Neisseria meningitidis, wherein the glycan moiety is covalently linked to the carrier through a linker. Also provided herein are a mixture of the glycan conjugates thereof, immmunogenic compositions thereof, and kits thereof. The invention further provides methods of using the synthetic glycan conjugates and immunogenic compositions thereof to treat and/or reduce the risk of infectious diseases such as bacterial infections.