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公开(公告)号：US11480391B2
公开(公告)日：2022-10-25
申请号：US16348421
申请日：2017-11-08
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Chung-Yi Wu
Abstract: Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.
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公开(公告)号：US20200179503A1
公开(公告)日：2020-06-11
申请号：US16442334
申请日：2019-06-14
Applicant: Academia Sinica
Inventor： Shih-Hsiung Wu , Chung-Yi Wu , I-Ming Lee , Feng-Ling Yang
Abstract: Disclosed herein is a glycocojugate vaccine conferring protection against a Gram negative pathogen infection, a method of manufacturing the glycoconjugate vaccine, and use of the glycocojugate vaccine for treating bacterial infection. The glycocojugate vaccine of the present disclosure has the structure of formula (I), wherein, L is a maleimide-type linker, which is connected to the carrier protein via a maleimide bond formed therebetween; and n and m are respectively an integral or a non-integral number between 2 and 20.
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公开(公告)号：US20190085062A1
公开(公告)日：2019-03-21
申请号：US15989860
申请日：2018-05-25
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC: C07K16/18 , G01N33/574
Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, lung, breast, mouse, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervix, ovary, and/or prostate cancer.
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公开(公告)号：US11377485B2
公开(公告)日：2022-07-05
申请号：US16150164
申请日：2018-10-02
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Chung-Yi Wu
Abstract: Methods for making modified Fc regions of antibodies and antibody fragments, both human and humanized, and having enhanced stability and efficacy, are provided. Antibodies comprising Fc regions with core fucose residues removed, and attached to oligosaccharides comprising terminal sialyl residues, are provided. Antibodies comprising homogeneous glycosylation of Fc regions with specific oligosaccharides are provided. Fc regions conjugated with homogeneous glycoforms of monosaccharides and trisaccharides, are provided. Methods of preparing human antibodies with modified Fc using glycan engineering, are provided.
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公开(公告)号：US11103567B2
公开(公告)日：2021-08-31
申请号：US16442334
申请日：2019-06-14
Applicant: Academia Sinica
Inventor： Shih-Hsiung Wu , Chung-Yi Wu , I-Ming Lee , Feng-Ling Yang
Abstract: Disclosed herein is a glycoconjugate vaccine conferring protection against a Gram negative pathogen infection, a method of manufacturing the glycoconjugate vaccine, and use of the glycoconjugate vaccine for treating bacterial infection. The glycoconjugate vaccine of the present disclosure has the structure of formula (I), wherein, L is a maleimide-type linker, which is connected to the carrier protein via a maleimide bond formed therebetween; and n and m are independently an integral or a non-integral number between 2 and 20.
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Patent Agency Ranking
公开(公告)号：US20200038497A1
公开(公告)日：2020-02-06
申请号：US16338501
申请日：2017-10-03
Applicant: NATIONAL TAIWAN UNIVERSITY , Academia Sinica
Inventor： Jin-Town Wang , Shih-Hsiung Wu , Chung-Yi Wu
IPC: A61K39/108 , C08B37/00 , A61P31/04
Abstract: The disclosure provides various immunogens comprising a repeat unit of saccharide of Klebsiella pneumoniae CPS, which has a formula selected from the group consisting of Formulae (I) to (VI) as described herein. Also provided are vaccines including one or more immunogens selected from Formula (I) to (VI) and methods of eliciting an immune response against a Klebsiella pneumoniae and preventing infection of Klebsiella pneumoniae by using an immunogen of the invention.
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公开(公告)号：US10407673B2
公开(公告)日：2019-09-10
申请号：US16011622
申请日：2018-06-18
Applicant: CHO Pharma Inc. , Academia Sinica
Inventor： Nan-Horng Lin , Lin-Ya Huang , Sachin S Shivatare , Li-Tzu Chen , Chi-Huey Wong , Chung-Yi Wu , Ting Cheng
Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.
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公开(公告)号：US10336784B2
公开(公告)日：2019-07-02
申请号：US15453836
申请日：2017-03-08
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Chung-Yi Wu , Sachin S. Shivatare
IPC: C07H5/06 , A61K31/702 , C12N9/10 , C07K16/10 , C12P19/04 , G01N33/50 , G01N33/532 , G01N33/68 , C08B37/00 , G01N33/569 , C12P19/28
Abstract: The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycans and glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.
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公开(公告)号：US20190177435A1
公开(公告)日：2019-06-13
申请号：US16184203
申请日：2018-11-08
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Tsui-Ling Hsu , Yi-Wei Lou , Chih-Wei Lin , Shih-Chi Yeh , Chung-Yi Wu , Han-Chung Wu
IPC: C07K16/44 , C07K16/30 , G01N33/574 , C07K16/18
Abstract: Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and/or prostate cancer.
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公开(公告)号：US10086054B2
公开(公告)日：2018-10-02
申请号：US14392341
申请日：2014-06-26
Applicant: ACADEMIA SINICA
Inventor： Chi-Huey Wong , Chung-Yi Wu , Hong-Yang Chuang , Chien-Tai Ren
IPC: C07H15/04 , A61K39/00 , A61K39/385 , A61K31/7028 , C07K14/47 , A61K49/00 , C07H15/10 , C07H15/14
Abstract: Described herein are synthetic glycan conjugates, immunogenic compositions thereof, vaccines thereof, and kits thereof. The present invention further provides methods of using the synthetic glycan conjugates, immunogenic compositions, or vaccines thereof to treat and/or prevent and/or diagnose proliferative diseases such as cancer. The provided glycan conjugate comprises a carrier and a glycan moiety of Formula (I-i) or Formula (I-ii): (structurally represented).
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