公开(公告)号：US20220267382A1

公开(公告)日：2022-08-25

申请号：US17627212

申请日：2020-09-18

Applicant: ACADEMIA SINICA

Inventor： Yu-Chan CHAO ,  Chih-Hsuan TSAI ,  Chia-Jung CHANG ,  Sung-Chan WEI ,  Lin-Li LIAO ,  Huei-Ru LO

IPC: C07K14/005 ,  A61P31/16

Abstract: Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.