公开(公告)号：US20230160892A1

公开(公告)日：2023-05-25

申请号：US17913986

申请日：2021-03-22

Applicant: Ming-Che SHIH ,  Academia Sinica

Inventor： Yu-Chan CHAO ,  Sung-Chan WEI ,  Huei-Ru LO ,  Chih-Hsuan TSAI ,  Yu-Wen LO ,  Wei-Ting HSU ,  Chuan-Yu LIAO

IPC: G01N33/569 ,  C12N15/86 ,  C07K14/435 ,  C07K14/005

CPC classification number: G01N33/56983 ,  C12N15/86 ,  C07K14/43572 ,  C07K14/005 ,  C12N2710/14022 ,  C12N2710/14042 ,  C12N2710/14052 ,  C12N2770/20034 ,  G01N2469/20 ,  A61K39/00

Abstract: Disclosed herein are recombinant viruses and/or insect cells suitable for detecting the infection of a pathogen in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the pathogen or not, so that proper course of treatment may be assigned to the subject. Also disclosed herein is a vaccine for the prophylaxis and/or treatment of infection caused by said pathogen.

公开(公告)号：US20220267382A1

公开(公告)日：2022-08-25

申请号：US17627212

申请日：2020-09-18

Applicant: ACADEMIA SINICA

Inventor： Yu-Chan CHAO ,  Chih-Hsuan TSAI ,  Chia-Jung CHANG ,  Sung-Chan WEI ,  Lin-Li LIAO ,  Huei-Ru LO

IPC: C07K14/005 ,  A61P31/16

Abstract: Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.