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公开(公告)号：US20250028163A1
公开(公告)日：2025-01-23
申请号：US18909323
申请日：2024-10-08
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20240219705A1
公开(公告)日：2024-07-04
申请号：US18608490
申请日：2024-03-18
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
CPC classification number: G02B21/365 , G02B21/06 , G02B21/26 , G06V10/141 , G06V10/25 , G06V20/693 , H04N23/56 , H04N23/74
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20230176063A1
公开(公告)日：2023-06-08
申请号：US17913101
申请日：2021-03-19
Applicant: Academia Sinica
Inventor： Chih-Wei CHANG , Yi-De CHEN , Jung-Chi LIAO
IPC: G01N33/58
CPC classification number: G01N33/581
Abstract: Compositions including photoreactive and cleavable probes and methods of using the probes. The probes may include a tag conjugatable to a label, a cleavable linker linkable to a bait molecule, and a light activated warhead. The compositions and methods may be useful for analyzing biomolecules.
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公开(公告)号：US20180367717A1
公开(公告)日：2018-12-20
申请号：US16013663
申请日：2018-06-20
Applicant: ACADEMIA SINICA
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
Abstract: A microscope-based system and a method for image-guided microscopic illumination are provided. The microscope-based system for image-guided microscopic illumination comprises a microscope, an illuminating assembly, an imaging assembly, a first processing module, and a second processing module. The microscope comprises a stage, and the stage is configured to be loaded with a sample. The imaging assembly comprises a camera. The processing modules are coupled to the microscope, the imaging assembly, and the illuminating assembly. A processing module controls the imaging assembly such that the camera acquires an image or images of the sample of a first field of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion, so as to determine an interested region in the image and so as to obtain a coordinate information regarding to the interested region, and the coordinate information regarding to the interested region is transmitted to a processing module, where this module controls the illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region. It is therefore an object to process the proteins, lipids, nucleic acids, or biochemical species in an area of interest specified by fluorescent signals or structural signature of biological images. Additional object is to collect a large amount of proteins, lipids, and nucleic acids through high content labeling and purification in order to identify proteins, lipids, nucleic acids, or biochemical species of interest in the area of interest by analytical approaches including mass spectrometry and sequencing.
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公开(公告)号：US20250028162A1
公开(公告)日：2025-01-23
申请号：US18909298
申请日：2024-10-08
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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Patent Agency Ranking
公开(公告)号：US20240219703A1
公开(公告)日：2024-07-04
申请号：US18608452
申请日：2024-03-18
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
CPC classification number: G02B21/365 , G02B21/06 , G02B21/26 , G06V10/141 , G06V10/25 , G06V20/693 , H04N23/56 , H04N23/74
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20220159157A1
公开(公告)日：2022-05-19
申请号：US17592211
申请日：2022-02-03
Applicant: ACADEMIA SINICA
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20250052993A1
公开(公告)日：2025-02-13
申请号：US18922794
申请日：2024-10-22
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20240219704A1
公开(公告)日：2024-07-04
申请号：US18608479
申请日：2024-03-18
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
CPC classification number: G02B21/365 , G02B21/06 , G02B21/26 , G06V10/141 , G06V10/25 , G06V20/693 , H04N23/56 , H04N23/74
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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公开(公告)号：US20230418041A1
公开(公告)日：2023-12-28
申请号：US18464125
申请日：2023-09-08
Applicant: Academia Sinica
Inventor： Jung-Chi LIAO , Yi-De CHEN , Chih-Wei CHANG , Weng Man CHONG
CPC classification number: G02B21/365 , G02B21/26 , G02B21/06 , G06V10/25 , G06V10/141 , G06V20/693 , H04N23/56 , H04N23/74
Abstract: A system and method for image-guided microscopic illumination are provided. A processing module controls an imaging assembly such that a camera acquires an image or images of a sample in multiple fields of view, and the image or images are automatically transmitted to a processing module and processed by the first processing module automatically in real-time based on a predefined criterion so as to determine coordinate information of an interested region in each field of view. The processing module also controls an illuminating assembly to illuminate the interested region of the sample according to the received coordinate information regarding to the interested region, with the illumination patterns changing among the fields of view.
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