公开(公告)号：US20210113610A1

公开(公告)日：2021-04-22

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K33/30 ,  A61K31/198 ,  A61K9/00 ,  A61K9/68 ,  A61P25/00 ,  G01N33/68 ,  A01K67/027 ,  A61K49/00 ,  A23L33/16 ,  A23L33/175 ,  A23K20/142 ,  A23K20/20

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US12059433B2

公开(公告)日：2024-08-13

申请号：US17077504

申请日：2020-10-22

Applicant: ACADEMIA SINICA

Inventor： Yi-Ping Hsueh ,  Tzyy-Nan Huang

IPC: A61K31/198 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/20 ,  A23L33/16 ,  A23L33/175 ,  A61K9/00 ,  A61K9/68 ,  A61K33/30 ,  A61K49/00 ,  A61P25/00 ,  G01N33/68

CPC classification number: A61K33/30 ,  A01K67/0276 ,  A01K67/0278 ,  A23K20/142 ,  A23K20/30 ,  A23L33/16 ,  A23L33/175 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K31/198 ,  A61K49/0008 ,  A61P25/00 ,  G01N33/6806 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A23V2002/00

Abstract: The present invention relates to a method for treating autism spectrum disorders (ASD) or ASD-like symptom, particularly by administering a zinc ion source and/or a serine component e.g. D-serine or its precursor/analogue, optionally in combination with a mixture of branched-chain amino acids (BCAAs). The present invention also relates to a combination, kit or composition for performing the method for treatment as described herein. Further described is use of a zinc ion source and/or a serine component and optional BCAAs for manufacturing a medicament for treating a symptom or disease characteristics associated with ASD or ASD-associated disorder or as a food supplement for ameliorating relevant symptoms in a subject in need thereof. The present invention further provides an animal model for autistic spectrum disorder (ASD) with deficient CTTNBP2 gene, and a method for identifying an ingredient effective in the treatment of ASD by using such animal model.

公开(公告)号：US20160120858A1

公开(公告)日：2016-05-05

申请号：US14932812

申请日：2015-11-04

Applicant: ACADEMIA SINICA ,  INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION

Inventor： Eun-Joon KIM ,  Eun-Jae LEE ,  Hye-Jin LEE ,  Yi-Ping HSUEH ,  Tzyy-Nan Huang ,  Jae-Young KOH

IPC: A61K31/47 ,  A61K9/00

CPC classification number: A61K31/47 ,  A61K9/0019

Abstract: The present invention relates to a pharmaceutical composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a food composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及用于治疗孤独症谱系障碍的药物组合物，其包括氯碘喹啉或其药学上可接受的盐。 此外，本发明涉及用于治疗自闭症谱系障碍的食品组合物，其包括氯碘喹啉或其药学上可接受的盐。