公开(公告)号：US11630102B2

公开(公告)日：2023-04-18

申请号：US16484948

申请日：2018-02-08

Applicant: ACADEMIA SINICA

Inventor： Yuan-Tsong Chen ,  Yi-Ching Lee ,  Jer-Yuam Wu ,  Hsiao-Jung Kao

IPC: A01K67/027 ,  G01N33/50 ,  A61P19/00 ,  A61P35/00 ,  A61K31/409 ,  A61K36/21

Abstract: A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.

公开(公告)号：US20230243810A1

公开(公告)日：2023-08-03

申请号：US18116952

申请日：2023-03-03

Applicant: ACADEMIA SINICA

Inventor： Yuan-Tsong Chen ,  Yi-Ching Lee ,  Jer-Yuarn Wu ,  Hsiao-Jung Kao

IPC: G01N33/50 ,  A61P19/00 ,  A61P35/00 ,  A01K67/027 ,  A61K31/409 ,  A61K36/21

CPC classification number: G01N33/502 ,  A61P19/00 ,  A61P35/00 ,  A01K67/0278 ,  A61K31/409 ,  A61K36/21 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/0331 ,  G01N2500/10

Abstract: A method of inhibiting an overactive fibroblast growth factor receptor 3 (FGFR3) in a cell by contacting the cell with a composition that contains an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Also disclosed is a method for treating a disorder associated with an overactive FGFR3 with a composition containing an effective amount of Pheophorbide a, Pyropheophorbide a, or an active derivative thereof. Further, a composition for treating a disorder associated with an overactive FGFR3 is described. The composition contains an ethanol extract of Amaranthus viridis.