公开(公告)号：US20230338501A1

公开(公告)日：2023-10-26

申请号：US18024703

申请日：2021-07-04

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Neal VAN HOEVEN ,  Emily VOIGT

IPC: A61K39/12 ,  C12N7/00 ,  A61P31/14 ,  A61K9/107

CPC classification number: A61K39/12 ,  C12N7/00 ,  A61P31/14 ,  A61K9/1075 ,  A61K2039/53

Abstract: This disclosure provides ribonucleic acid (RNA) polynucleotides encoding replication-competent viral genomes that, when introduced to a subject, induce an active viral replication. The RNA may be provided naked or with an artificial RNA delivery system. The viral genome may be a full-length genome of an attenuated viral strain. For example, the RNA may encode an attenuated Chikungunya or yellow fever virus. The artificial RNA delivery system may be a lipid particle such as a lipid nanoparticle (LNP), a nanostructure lipid carrier (NLC), or a cationic nanoemulsion (CNE). This disclosure also provides methods of inducing an immune response, including protective immunity, by administering to a subject an RNA polynucleotide that encodes a replication-competent viral genome in an amount sufficient to cause viral replication in the subject. The immune response may include inducing the production of neutralizing antibodies at a level comparable to inoculation with a live-attenuated virus.

公开(公告)号：US20230310569A1

公开(公告)日：2023-10-05

申请号：US18024727

申请日：2021-07-04

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Emily VOIGT

IPC: A61K39/12 ,  A61K39/39

CPC classification number: A61K39/12 ,  A61K39/39 ,  A61K2039/53

Abstract: The present application discloses a genetically-adjuvanted RNA vaccine including one or more genes encoding immune stimulatory adjuvants in the genetic material of the vaccine backbone. The vaccine may be applied to enhance the magnitude, diversity, and durability of RNA vaccine-stimulated immunity in a subject.