公开(公告)号：US11510875B2

公开(公告)日：2022-11-29

申请号：US14377488

申请日：2013-02-07

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher Fox ,  Steven G. Reed ,  Susan Baldwin ,  Thomas Vedvick

IPC: A61K9/113 ,  A61K39/39 ,  A61K39/015 ,  A61K39/12 ,  A61K9/107 ,  A61K47/06 ,  A61K39/00 ,  A61K47/24 ,  A61K47/26

Abstract: Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emulsion is greater than about 9.