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公开(公告)号：US11185610B2
公开(公告)日：2021-11-30
申请号：US15739164
申请日：2016-08-11
发明人： Dar-Jen Hsieh , Ming-Yao Chang
IPC分类号： A61L15/00 , C07K14/78 , A61L27/24 , A61L27/56 , A61L27/36 , C07K1/36 , A61L27/20 , A61L27/52
摘要： Disclosed herein is a method of producing acellular cartilage grafts. The method includes steps of, subjecting a cartilage matrix derived from an animal to alkaline, disinfection and decelluarization treatments. The thus produced cartilage graft is devoid of any cellular matters, while maintaining the porosity and integrity of collagen fibers therein, thus is suitable as a xenograft for host cells to grown thereon. Also disclosed herein is a method for treating osteochondral disease of a subject, in which the present acellular cartilage graft is applied to a lesion site of the subject.
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公开(公告)号：US10660988B2
公开(公告)日：2020-05-26
申请号：US15738644
申请日：2016-12-13
发明人： Shing-Jye Chen , Fan-Wei Tseng , Kai-Chi Ku , Dar-Jen Hsieh
摘要： A method of producing an acellular cornea includes steps of subjecting a cornea of an animal to a decellularization process, and has not the step of treating the cornea with a protease, a chelating agent, a detergent, a glycerol, or a combination thereof. When a native cornea is processed by the method, the native structure and conformation of the native cornea are preserved while immunogenic matters are reduced to a level that the thus produced cornea may serve as a three-dimensional scaffold for host cells to grow thereon after transplantation.
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公开(公告)号：US11951233B2
公开(公告)日：2024-04-09
申请号：US17251790
申请日：2019-09-11
发明人： Dar-Jen Hsieh , Chao-Yi Wei , Chao-Chin Chao , Jer-Cheng Kuo , Yi-Ping Lai , Srinivasan Periasamy
CPC分类号： A61L27/3691 , A61L27/3625 , A61L27/3687 , A61L2430/20 , A61L2430/40
摘要： Provided are methods of producing an acellular organ. The method includes the steps of, subjecting an organ derived from an animal to a static supercritical fluid (SCF) treatment followed by a dynamic SCF treatment. Optionally, the method of the present disclosure further includes a hypertonic and a hypotonic treatments prior to the static SCF treatment, and/or a neutralizing treatment after the dynamic SCF treatment. Also disclosed herein are acellular organs produced by the present method.
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公开(公告)号：US10881761B2
公开(公告)日：2021-01-05
申请号：US15739163
申请日：2016-08-11
发明人： Jun-Jie Wang , Pei-Hua Tsai , Kai-Chi Ku , Dar-Jen Hsieh
摘要： Disclosed herein is a method of producing collagen particles. Each of the collagen particle is characterized in having a particle size of about 10-250 μm, in which the integrity of collagen fibers therein is relatively intact.
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