公开(公告)号：US20240174620A1

公开(公告)日：2024-05-30

申请号：US18280120

申请日：2022-03-04

Applicant: ADAMA AGAN LTD.

Inventor： Michael GRABARNICK ,  Sergio NAHMOUD ,  Daniel MELIKER ,  Lior ZISERMAN ,  Ashok Kumar JHA ,  Revanappa Vasantrao GALGE

IPC: C07D239/54 ,  A01N43/54 ,  A01P13/00

CPC classification number: C07D239/54 ,  A01N43/54 ,  A01P13/00

Abstract: The present invention relates to novel solid forms of saflufenacil-sodium or saflufenacil-potassium. The present invention further relates to a process of making said novel solid forms of saflufenacil-sodium or saflufenacil-potassium. Still further, the present invention relates to the use of the novel solid forms of saflufenacil-sodium or saflufenacil-potassium.

公开(公告)号：US20250115560A1

公开(公告)日：2025-04-10

申请号：US18294602

申请日：2022-08-09

Applicant: ADAMA AGAN LTD.

Inventor： Michael GRABARNICK ,  Ashok Kumar JHA ,  Revanappa Vasantrao GALGE

IPC: C07D239/557

Abstract: The invention relates to a novel and efficient saflufenacil synthesis and the preparation of novel key intermediates in the process of Saflufenacil synthesis. The process includes preparing compounds of the Formula I wherein R1i is a hydrogen, C1-12 straight or branched alkyl, which may be substituted with 1 or more substituents, a C3-10 cycloalkyl, which may be substituted with 1 or more substituents, a C6-10 aromatic ring which may be substituted with 1 or more substituents, a C5-10 heteroaromatic ring, which may be substituted with 1 or more substituents; R2 is a hydrogen or methyl.

公开(公告)号：US20170081299A1

公开(公告)日：2017-03-23

申请号：US15364688

申请日：2016-11-30

Applicant: ADAMA AGAN LTD.

Inventor： Omer TZOR ,  Michael GRABARNICK

IPC: C07D261/08

CPC classification number: C07D261/08

Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20250066297A1

公开(公告)日：2025-02-27

申请号：US18719594

申请日：2022-12-15

Applicant: ADAMA AGAN LTD.

Inventor： Eran FOGLER ,  Michael GRABARNICK ,  David SILVER

IPC: C07D207/277 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04

Abstract: The present invention relates to various compounds, which are novel and useful intermediates in novel methods for preparation of certain compounds referred to as Saturated Targets and amorphous and crystal forms thereof, and certain marker compounds including Storage Marker compounds, methods for their preparation, their use, and compositions comprising them including methods to minimize their percentage content of Storage Markers in products and compositions of Saturated Target.

公开(公告)号：US20240217915A1

公开(公告)日：2024-07-04

申请号：US18552326

申请日：2022-03-22

Applicant: ADAMA AGAN LTD.

Inventor： Michael GRABARNICK ,  Ashok Kumar JHA ,  Revanappa Vasantrao GALGE

IPC: C07C201/16 ,  A01N43/54 ,  A01P13/00 ,  C07C201/08 ,  C07D239/54

CPC classification number: C07C201/16 ,  A01N43/54 ,  A01P13/00 ,  C07C201/08 ,  C07D239/54

Abstract: The present invention relates to a novel nitration process of 2-chloro-4-fluorobenzoic acid to 2-chloro-4-fluoro-5-ni-trobenzoic acid, 2-chloro-4-f luoro-3-nitrobenzoic acid and 3,5-dinitro-2-chloro-4-fluorobenzoic acid; purifying the crude reaction product; and recovering 2-chloro-4-fluoro-5-nitrobenzoic acid in an essentially pure form, which can be used in the synthesis of the herbicide saflufenacil.

公开(公告)号：US20160251323A1

公开(公告)日：2016-09-01

申请号：US15029063

申请日：2014-10-13

Applicant: ADAMA AGAN LTD.

Inventor： Omer TZOR ,  Michael GRABARNICK

IPC: C07D261/08

CPC classification number: C07D261/08

Abstract: A process for preparing isoxaflutole of formula (I) wherein the process comprises: admixing (5-cyclopropyl-4-isoxazolyl)[2-(methylthio)-4-(trifluoromethyl)phenyl]-methanone of formula (II) with acetic acid, acetic anhydride and hydrogen peroxide in the presence of a strong acid.

Abstract translation: 制备式（I）的异构肟基的方法，其中该方法包括：将式（II）的（5-环丙基-4-异恶唑基）[2-（甲硫基）-4-（三氟甲基）苯基] - 甲酮与乙酸混合， 乙酸酐和过氧化氢在强酸存在下进行。