公开(公告)号：US20240307406A1

公开(公告)日：2024-09-19

申请号：US18263402

申请日：2022-01-28

申请人： ADVANCED BIODESIGN

发明人： Mileidys PEREZ ,  Guillaume MARTIN

IPC分类号： A61K31/5375 ,  A61K31/265 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4409 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K31/5375 ,  A61K31/265 ,  A61K31/40 ,  A61K31/4402 ,  A61K31/4409 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04

摘要： The present invention relates to aminothiolesters compounds for use for modulating the immune response in a subject. In particular, said compounds are comprised in a lipidic nanocapsule. The invention further relates to a pharmaceutical composition and to combination products comprising at least one aminothiolester compound and an immune checkpoint inhibitor, and their use for the treatment of cancer.

公开(公告)号：US20220265845A1

公开(公告)日：2022-08-25

申请号：US17631046

申请日：2020-07-31

申请人： ADVANCED BIODESIGN

发明人： Ismail CEYLAN ,  Guillaume MARTIN ,  Mileidys PEREZ ,  Axelle BERROU

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61K31/265 ,  A61K31/22 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/222 ,  A61K31/27 ,  A61K31/40 ,  A61P35/00

摘要： The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of preparation and to these compounds for use as a medicament, in particular for the treatment or the prevention of cancer. The present invention further relates to an antibody drug conjugate comprising such compounds.