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1.发明申请公开(公告)号：US20180296548A1
公开(公告)日：2018-10-18
申请号：US15767339
申请日：2016-10-14
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/4453 , A61K31/255 , A61K31/5375 , A61P35/00 , A61P35/02 , G01N33/50
摘要： The present invention relates to the treatment of cancer in a subject, wherein cancer cells of said subject overproduce H2O2 and have a level of GSH below 0.5 nmol for 25 000 cells, with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate. It also relates to a method for selecting a subject suffering from a cancer and who will most likely benefit from a treatment with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate.
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公开(公告)号：US20240307406A1
公开(公告)日：2024-09-19
申请号：US18263402
申请日：2022-01-28
申请人： ADVANCED BIODESIGN
发明人： Mileidys PEREZ , Guillaume MARTIN
IPC分类号： A61K31/5375 , A61K31/265 , A61K31/40 , A61K31/4402 , A61K31/4409 , A61K45/06 , A61P35/00 , A61P37/04
CPC分类号： A61K31/5375 , A61K31/265 , A61K31/40 , A61K31/4402 , A61K31/4409 , A61K45/06 , A61P35/00 , A61P37/04
摘要： The present invention relates to aminothiolesters compounds for use for modulating the immune response in a subject. In particular, said compounds are comprised in a lipidic nanocapsule. The invention further relates to a pharmaceutical composition and to combination products comprising at least one aminothiolester compound and an immune checkpoint inhibitor, and their use for the treatment of cancer.
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公开(公告)号：US20180303773A1
公开(公告)日：2018-10-25
申请号：US15768468
申请日：2016-10-14
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/145 , A61P35/02 , G01N21/64 , G01N33/574 , G01N33/68 , G01N33/84
CPC分类号： A61K31/145 , A61K31/131 , A61K31/136 , A61K31/137 , A61K31/4453 , A61K31/498 , A61K31/5375 , A61K31/704 , A61K33/24 , A61K33/36 , A61K45/06 , A61K2300/00 , A61P35/02 , G01N21/64 , G01N33/57496 , G01N33/68 , G01N33/84 , G01N2440/00
摘要： The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase H2O2 level in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce H2O2 in comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.
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公开(公告)号：US20220265845A1
公开(公告)日：2022-08-25
申请号：US17631046
申请日：2020-07-31
申请人： ADVANCED BIODESIGN
发明人： Ismail CEYLAN , Guillaume MARTIN , Mileidys PEREZ , Axelle BERROU
IPC分类号： A61K47/68 , A61K47/54 , A61K31/265 , A61K31/22 , A61K31/4402 , A61K31/4406 , A61K31/222 , A61K31/27 , A61K31/40 , A61P35/00
摘要： The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of preparation and to these compounds for use as a medicament, in particular for the treatment or the prevention of cancer. The present invention further relates to an antibody drug conjugate comprising such compounds.
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公开(公告)号：US20190233871A1
公开(公告)日：2019-08-01
申请号：US16320071
申请日：2017-07-27
申请人： ADVANCED BIODESIGN , Centre national de la recherche scientifique , Université Claude Bernard Lyon 1
CPC分类号： C12Q1/007 , C12Q1/32 , C12Q2334/20 , C12Q2334/40
摘要： The invention relates to a specific substrate on an ALDH isoenzyme, to a composition comprising at least one such substrate, to a diagnostic marker comprising such a substrate, and to the uses thereof and associated methods.
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6.发明申请公开(公告)号：US20190169313A1
公开(公告)日：2019-06-06
申请号：US16309860
申请日：2017-06-14
申请人： ADVANCED BIODESIGN
IPC分类号： C07K16/44 , G01N33/53 , G01N33/68 , G01N33/558
摘要： The present invention concerns an ex vivo method for the monitoring of apoptosis which is based on the detection of free gamma-glutamyl-L-epsilon-Lysine (GGEL) in a biological sample of a subject with a monoclonal antibody specific to GGEL. The invention also relates to the monoclonal antibody specific to GGEL, as well as to diagnostic kits containing such a ligand.
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7.发明公开公开(公告)号：US20230149378A1
公开(公告)日：2023-05-18
申请号：US17993003
申请日：2022-11-23
申请人： ADVANCED BIODESIGN
IPC分类号： A61K31/4453 , A61K31/5375 , A61K31/131 , A61K31/136 , A61K31/137 , G01N33/84 , G01N33/68 , G01N33/574 , A61P35/02 , A61P35/00 , A61K31/255 , G01N33/50
CPC分类号： A61K31/4453 , A61K31/5375 , A61K31/131 , A61K31/136 , A61K31/137 , G01N33/84 , G01N33/68 , G01N33/574 , A61P35/02 , A61P35/00 , A61K31/255 , G01N33/5011 , G01N2800/52
摘要： The present invention relates to the treatment of cancer in a subject, wherein cancer cells of said subject overproduce H2O2 and have a level of GSH below 0.5 nmol for 25 000 cells, with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate. It also relates to a method for selecting a subject suffering from a cancer and who will most likely benefit from a treatment with aminothiolester compounds or pharmaceutically acceptable salts thereof, in particular with S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, more particularly with 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate.
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