公开(公告)号：US20150258511A1

公开(公告)日：2015-09-17

申请号：US14657550

申请日：2015-03-13

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: B01F13/00

CPC classification number: B01F13/00 ,  B01F7/162 ,  B01F7/1695 ,  B01F13/0032 ,  B01F15/00837 ,  B01F15/0085 ,  B01F2215/0032 ,  B01F2215/0073 ,  B65D77/06

Abstract: A mixing system and mixing arrangement are provided. The mixing system includes a rigid container including an integral support plate; a mixing assembly supported on the integral support plate, the mixing assembly including a pliable enclosure containing a fluid and a mixing device, a portion of the mixing device extending from the pliable enclosure and adapted to be detachably coupled to a drive mechanism; and a first plate detachably secured to the rigid container. The pliable enclosure is in compression between the first plate and the integral support plate. The mixing arrangement includes a docking station including a drive cradle and a drive mechanism, a rigid container removably positioned within the drive cradle, a mixing assembly positioned within the rigid container, and a first plate configured to be detachably secured to the rigid container.

Abstract translation: 提供混合系统和混合装置。 该混合系统包括一个包含整体支撑板的刚性容器; 支撑在整体支撑板上的混合组件，所述混合组件包括容纳流体和混合装置的柔性外壳，所述混合装置的一部分从柔性外壳延伸并适于可拆卸地联接到驱动机构; 以及可拆卸地固定到刚性容器的第一板。 柔性外壳在第一板和整体支撑板之间处于压缩状态。 混合装置包括对接站，该对接站包括驱动支架和驱动机构，可拆卸地定位在驱动支架内的刚性容器，位于刚性容器内的混合组件以及被配置为可拆卸地固定到刚性容器的第一板。

公开(公告)号：US20140083170A1

公开(公告)日：2014-03-27

申请号：US13974932

申请日：2013-08-23

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: G01M3/32

CPC classification number: G01M3/3218 ,  G01M3/3263

Abstract: A portable flexible container integrity test device for conducting integrity testing of flexible containers is disclosed. The test device is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The test device includes a programmable logic controller (PLC), a pressure transducer in electronic communication with the PLC, a power source configured to provide electrical power to the PLC, a blower in electronic communication with the PLC, a gas delivery pathway in selective fluid communication with the blower, and a human/machine interface in electronic communication with the PLC. The device is portable and configured to fluidly connect to a flexible container via the gas delivery pathway.

Abstract translation: 公开了用于进行柔性容器的完整性测试的便携式柔性容器完整性测试装置。 测试装置特别适用于以保持容器的无菌性质的方式测试无菌柔性膜袋，并且通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。 测试装置包括可编程逻辑控制器（PLC），与PLC电子通信的压力传感器，被配置为向PLC提供电力的电源，与PLC电子通信的鼓风机，选择性流体中的气体输送路径 与鼓风机的通信，以及与PLC电子通信的人机界面。 该装置是便携式的并且构造成经由气体输送路径流体地连接到柔性容器。

公开(公告)号：US20140007655A1

公开(公告)日：2014-01-09

申请号：US13934684

申请日：2013-07-03

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: G01M3/26

CPC classification number: G01M3/26

Abstract: A pressure decay testing system including a testing device for determining the reliability of connectors is provided and includes a pneumatic cylinder that raises and lowers a sealing member that closes a second end of a connector inserted in the device. A base member is adjacent pneumatic cylinder and includes a receiving surface having at least one receiving member for holding the connector. A channel is disposed therethrough though the receiving surface of the base member and aligns with an inner bore of the connector inserted in the testing device. An air line is attached to base member fluidly connecting inner bore of the connector with decay tester. Decay tester introduces a pressure differential through the channel to reach a predetermined set point pressure when the connector is closed by the testing device. Decay tester is configured to measure a change in pressure over time with respect to the predetermined set point.

Abstract translation: 提供了包括用于确定连接器的可靠性的测试装置的压力衰减测试系统，并且包括气动缸，其升高并降低了封闭插入到装置中的连接器的第二端的密封构件。 基座构件邻近气缸，并且包括具有用于保持连接器的至少一个接收构件的接收表面。 通道穿过基底构件的接收表面设置并与插入测试装置中的连接器的内孔对准。 将空气管线连接到基座部件上，使连接器的内孔与衰减测试器流体连接。 当连接器被测试装置关闭时，衰减测试仪通过通道引入压差以达到预定的设定点压力。 衰减测试器被配置成测量相对于预定设定点的时间上的压力变化。

公开(公告)号：US20150290448A1

公开(公告)日：2015-10-15

申请号：US14476900

申请日：2014-09-04

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: A61M39/10 ,  A61M39/16 ,  A61M39/18

CPC classification number: A61J1/2051 ,  A61J1/201 ,  A61J1/2048 ,  A61M39/10 ,  A61M39/1055 ,  A61M39/12 ,  A61M39/16 ,  A61M39/18 ,  A61M2039/1072 ,  A61M2039/2433 ,  A61M2039/2473 ,  B65B3/003

Abstract: An aseptic connector assembly and a method of aseptically transferring fluid are provided. The aseptic connector assembly includes a body portion, the body portion having a receptacle configured to receive a corresponding fill connector; a pivot portion adjustably disposed within and extending partially from the body portion, the pivot portion having a channel formed therein; and a conduit portion axially slidably disposed within the channel formed in the pivot portion. The pivot portion comprises a ready position and an operative position, the pivot portion being adjustable from the ready position to the operative position via relative movement with respect to the body portion. The method includes providing an aseptic connector in a ready position, coupling a flexible tubing and a fill connector to the aseptic connector, moving a pivot portion to an operative position, axially sliding the conduit portion into the fill connector, and transferring a fluid through the connector.

Abstract translation: 提供无菌连接器组件和无菌转移流体的方法。 所述无菌连接器组件包括主体部分，所述主体部分具有被配置为容纳相应的填充连接器的插座; 枢转部分可调节地设置在主体部分内并部分地从主体部分延伸，枢转部分具有形成在其中的通道; 以及导管部分，其轴向可滑动地设置在形成在枢转部分中的通道内。 枢转部分包括就绪位置和操作位置，枢转部分可以通过相对于主体部分的相对运动从就绪位置调整到操作位置。 该方法包括将无菌连接器提供在就绪位置，将柔性管和填充连接器连接到无菌连接器，将枢轴部分移动到操作位置，将导管部分轴向滑动到填充连接器中，以及将流体通过 连接器。

公开(公告)号：US20160001242A1

公开(公告)日：2016-01-07

申请号：US14321120

申请日：2014-07-01

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: B01F13/02

CPC classification number: B01F13/0238 ,  B01F3/04248 ,  B01F11/0082 ,  B01F15/0085 ,  C12M23/14 ,  C12M29/06

Abstract: A plunge-mixing bag arrangement includes a flexible mixing bag defining a mixing region, and a shaft extending from outside of the flexible mixing bag into the mixing region, the shaft comprising a sparger within the mixing region. The sparger comprises an interior channel and ports extending from the interior channel. The shaft is capable of axial movement within the bag to fracture gas bubbles being released from the interior channel through the ports. A plunge-mixing system includes a mechanism for raising and lowering the shaft.

Abstract translation: 插入式混合袋装置包括限定混合区域的柔性混合袋和从柔性混合袋的外部延伸到混合区域中的轴，该轴在混合区域内包括喷雾器。 喷射器包括内部通道和从内部通道延伸的端口。 轴能够在袋内轴向运动，以破裂通过端口从内部通道释放的气泡。 插入式混合系统包括用于升高和降低轴的机构。

公开(公告)号：US20140083169A1

公开(公告)日：2014-03-27

申请号：US13974771

申请日：2013-08-23

Applicant: ADVANCED SCIENTIFICS, INC.

Inventor： Rudolf PAVLIK

IPC: G01M3/32

CPC classification number: G01M3/3218 ,  G01M3/3263

Abstract: A portable test device and related method are disclosed for conducting integrity testing of flexible containers. The test is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The decay in pressure is measured over a predetermined period of time; if pressure loss does not exceed a predetermined threshold the integrity of the bag is confirmed and it can be filled without further manipulation of the container that may result in introducing flaws.

Abstract translation: 公开了用于进行柔性容器的完整性测试的便携式测试装置和相关方法。 该测试对于以保持容器的无菌性质的方式测试无菌柔性膜袋特别有用，并通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。 在预定的时间段内测量压力衰减; 如果压力损失不超过预定阈值，则确认袋的完整性，并且可以在不进一步操纵可能导致缺陷的容器的情况下填充袋。