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公开(公告)号:US10654921B2
公开(公告)日:2020-05-19
申请号:US16321020
申请日:2017-07-26
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Simeon Cua , Andre Boon Hwa Choo , Heng Liang Tan , Wey Jia Fong , Vanessa Mei Yee Ding , Leonard Wen Yan Leong
IPC: A61K39/395 , C07K16/18 , A61K47/68 , A61P35/00 , G01N33/574 , A61K31/282 , A61K31/337 , A61K31/5377 , A61K38/17 , C07K14/705 , A61K39/00
Abstract: The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.
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公开(公告)号:US11820821B2
公开(公告)日:2023-11-21
申请号:US17560232
申请日:2021-12-22
Inventor: Hau Wan Leung , Andre Boon Hwa Choo , Mei Yee Vanessa Ding , Shao Weng Daniel Tan , Narayanan Gopalakrishna Iyer
IPC: C07K16/28 , A61P35/00 , G01N33/574 , A61K47/64 , A61K47/68 , C07K16/44 , A61K51/10 , C07K16/30 , A61K39/00
CPC classification number: C07K16/2803 , A61K47/6415 , A61K47/6857 , A61K51/1048 , A61P35/00 , C07K16/30 , C07K16/44 , G01N33/57473 , A61K2039/505 , A61K2039/55 , C07K2317/732
Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
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公开(公告)号:US12227570B2
公开(公告)日:2025-02-18
申请号:US18383043
申请日:2023-10-23
Inventor: Hau Wan Leung , Andre Boon Hwa Choo , Mei Yee Vanessa Ding , Shao Weng Daniel Tan , Narayanan Gopalakrishna Iyer
IPC: C07K16/28 , A61K39/00 , A61K47/64 , A61K47/68 , A61K51/10 , A61P35/00 , C07K16/30 , C07K16/44 , G01N33/574
Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
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公开(公告)号:US11697681B2
公开(公告)日:2023-07-11
申请号:US16848828
申请日:2020-04-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Simeon Cua , Andre Boon Hwa Choo , Heng Liang Tan , Wey Jia Fong , Vanessa Mei Yee Ding , Leonard Wen Yan Leong
IPC: A61K39/395 , C07K16/18 , A61K47/68 , A61P35/00 , G01N33/574 , A61K31/282 , A61K31/337 , A61K31/5377 , A61K38/17 , C07K14/705 , A61K39/00
CPC classification number: C07K16/18 , A61K31/282 , A61K31/337 , A61K31/5377 , A61K38/1774 , A61K39/3955 , A61K47/6819 , A61K47/6825 , A61K47/6843 , A61P35/00 , C07K14/70521 , G01N33/574 , A61K2039/505 , A61K2039/572 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/54 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/90 , C07K2319/03 , C07K2319/30 , C07K2319/33 , G01N2333/4718
Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS and a VHCDR3 having the amino acid sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSNDQKNYLA, a VLCDR2 having the amino acid sequence WASIRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. The present invention also relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence VYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS, and a VHCDR3 having the amino acid sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSSNQKNYLA, a VLCDR2 having the amino acid sequence WAS SRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. Compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof and kits comprising the antigen-binding protein, or antigen-binding fragment thereof are also provided.
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公开(公告)号:US11236160B2
公开(公告)日:2022-02-01
申请号:US16341052
申请日:2017-10-10
Inventor: Hau Wan Leung , Andre Boon Hwa Choo , Mei Yee Vanessa Ding , Shao Weng Daniel Tan , Narayanan Gopalakrishna Iyer
IPC: C07K16/28 , A61P35/00 , G01N33/574 , A61K47/64 , A61K47/68 , C07K16/44 , A61K51/10 , C07K16/30 , A61K39/00
Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
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公开(公告)号:US11124579B2
公开(公告)日:2021-09-21
申请号:US16498550
申请日:2018-03-29
Inventor: Chong Kok Teo , Andre Boon Hwa Choo , Wee Joo Chng
IPC: A61K47/68 , A61K47/64 , C07K16/28 , C07K16/30 , G01N33/574
Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
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公开(公告)号:US20200325246A1
公开(公告)日:2020-10-15
申请号:US16301382
申请日:2017-05-12
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor: Heng Liang TAN , Andre Boon Hwa Choo
IPC: C07K16/40 , A61K51/10 , A61K47/68 , A61K39/395
Abstract: The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
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公开(公告)号:US20240254221A1
公开(公告)日:2024-08-01
申请号:US18383043
申请日:2023-10-23
Inventor: Hau Wan LEUNG , Andre Boon Hwa Choo , Mei Yee Vanessa Ding , Shao Weng Daniel Tan , Narayanan Gopalakrishna Iyer
IPC: C07K16/28 , A61K39/00 , A61K47/64 , A61K47/68 , A61K51/10 , A61P35/00 , C07K16/30 , C07K16/44 , G01N33/574
CPC classification number: C07K16/2803 , A61K47/6415 , A61K47/6857 , A61K51/1048 , A61P35/00 , C07K16/30 , C07K16/44 , G01N33/57473 , A61K2039/505 , A61K2039/55 , C07K2317/732
Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.
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公开(公告)号:US11142585B2
公开(公告)日:2021-10-12
申请号:US16301382
申请日:2017-05-12
Applicant: Agency for Science, Technology and Research
Inventor: Heng Liang Tan , Andre Boon Hwa Choo
IPC: C07K16/40 , A61K47/68 , A61K39/395 , A61K51/10
Abstract: The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
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公开(公告)号:US20200024359A1
公开(公告)日:2020-01-23
申请号:US16498550
申请日:2018-03-29
Inventor: Chong Kok Teo , Andre Boon Hwa Choo , Wee Joo Chng
IPC: C07K16/30 , A61K47/64 , A61K47/68 , C07K16/28 , G01N33/574
Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.
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