公开(公告)号：US10654921B2

公开(公告)日：2020-05-19

申请号：US16321020

申请日：2017-07-26

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Simeon Cua ,  Andre Boon Hwa Choo ,  Heng Liang Tan ,  Wey Jia Fong ,  Vanessa Mei Yee Ding ,  Leonard Wen Yan Leong

IPC: A61K39/395 ,  C07K16/18 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574 ,  A61K31/282 ,  A61K31/337 ,  A61K31/5377 ,  A61K38/17 ,  C07K14/705 ,  A61K39/00

Abstract: The present invention relates to an antigen-binding protein, preferably a monoclonal antibody, against annexin A2 (ANXA2), comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence GYSITSGYSWH, a VHCDR2 of sequence YIHYSGSTKYNPSLKS and a VHCDR3 of sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSNDQKNYLA, a VLCDR2 of sequence WASIRES, and a VLCDR3 of sequence QQYYIYPLT. Also provided is an ANXA2 binding protein comprising (i) a heavy chain variable domain comprising a VHCDR1 of sequence VYSITSGYSWH; a VHCDR2 of sequence YIHYSGSTKYNPSLKS, and a VHCDR3 of sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 of sequence KSSQSLLYSSNQKNYLA, a VLCDR2 of sequence WASSRES, and a VLCDR3 of sequence QQYYIYPLT. The antibodies preferably bind to an N-linked glycan on ANXA2, and are internalised upon binding. They may be conjugated with cytotoxins and may be used in the treatment or detection of cancer.

公开(公告)号：US11820821B2

公开(公告)日：2023-11-21

申请号：US17560232

申请日：2021-12-22

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan Leung ,  Andre Boon Hwa Choo ,  Mei Yee Vanessa Ding ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/68 ,  C07K16/44 ,  A61K51/10 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K47/6415 ,  A61K47/6857 ,  A61K51/1048 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/57473 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/732

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US12227570B2

公开(公告)日：2025-02-18

申请号：US18383043

申请日：2023-10-23

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan Leung ,  Andre Boon Hwa Choo ,  Mei Yee Vanessa Ding ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/64 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US11697681B2

公开(公告)日：2023-07-11

申请号：US16848828

申请日：2020-04-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Simeon Cua ,  Andre Boon Hwa Choo ,  Heng Liang Tan ,  Wey Jia Fong ,  Vanessa Mei Yee Ding ,  Leonard Wen Yan Leong

IPC: A61K39/395 ,  C07K16/18 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574 ,  A61K31/282 ,  A61K31/337 ,  A61K31/5377 ,  A61K38/17 ,  C07K14/705 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K31/282 ,  A61K31/337 ,  A61K31/5377 ,  A61K38/1774 ,  A61K39/3955 ,  A61K47/6819 ,  A61K47/6825 ,  A61K47/6843 ,  A61P35/00 ,  C07K14/70521 ,  G01N33/574 ,  A61K2039/505 ,  A61K2039/572 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/54 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/90 ,  C07K2319/03 ,  C07K2319/30 ,  C07K2319/33 ,  G01N2333/4718

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS and a VHCDR3 having the amino acid sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSNDQKNYLA, a VLCDR2 having the amino acid sequence WASIRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. The present invention also relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence VYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS, and a VHCDR3 having the amino acid sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSSNQKNYLA, a VLCDR2 having the amino acid sequence WAS SRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. Compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof and kits comprising the antigen-binding protein, or antigen-binding fragment thereof are also provided.

公开(公告)号：US11236160B2

公开(公告)日：2022-02-01

申请号：US16341052

申请日：2017-10-10

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan Leung ,  Andre Boon Hwa Choo ,  Mei Yee Vanessa Ding ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/68 ,  C07K16/44 ,  A61K51/10 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US11124579B2

公开(公告)日：2021-09-21

申请号：US16498550

申请日：2018-03-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Chong Kok Teo ,  Andre Boon Hwa Choo ,  Wee Joo Chng

IPC: A61K47/68 ,  A61K47/64 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.

公开(公告)号：US20200325246A1

公开(公告)日：2020-10-15

申请号：US16301382

申请日：2017-05-12

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Heng Liang TAN ,  Andre Boon Hwa Choo

IPC: C07K16/40 ,  A61K51/10 ,  A61K47/68 ,  A61K39/395

Abstract: The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.

公开(公告)号：US20240254221A1

公开(公告)日：2024-08-01

申请号：US18383043

申请日：2023-10-23

Applicant: Singapore Health Services PTE LTD ,  Agency for Science, Technology and Research

Inventor： Hau Wan LEUNG ,  Andre Boon Hwa Choo ,  Mei Yee Vanessa Ding ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/64 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574

CPC classification number: C07K16/2803 ,  A61K47/6415 ,  A61K47/6857 ,  A61K51/1048 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/57473 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/732

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US11142585B2

公开(公告)日：2021-10-12

申请号：US16301382

申请日：2017-05-12

Applicant: Agency for Science, Technology and Research

Inventor： Heng Liang Tan ,  Andre Boon Hwa Choo

IPC: C07K16/40 ,  A61K47/68 ,  A61K39/395 ,  A61K51/10

Abstract: The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.

公开(公告)号：US20200024359A1

公开(公告)日：2020-01-23

申请号：US16498550

申请日：2018-03-29

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Chong Kok Teo ,  Andre Boon Hwa Choo ,  Wee Joo Chng

IPC: C07K16/30 ,  A61K47/64 ,  A61K47/68 ,  C07K16/28 ,  G01N33/574

Abstract: An antigen-binding protein, or an antigen-binding fragment thereof that binds to a Lewis X type glycan on SLAMF7, comprising (1) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYTFTSYWIH; a VHCDR2 having the amino acid sequence EINPSNGRTNFNEKFKN and a VHCDR3 having the amino acid sequence VDYDEAY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence RSSKSLLHSNGITYLY, a VLCDR2 having the amino acid sequence QMSNLAS, and a VLCDR3 having the amino acid sequence AQNLELWT is provided. Methods of using the antibody for detecting or treating cancer, and a kit comprising the antibody are also provided.