公开(公告)号：US20190110739A1

公开(公告)日：2019-04-18

申请号：US16090172

申请日：2017-03-28

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL SKIN CENTRE (SINGAPORE) PTE LTD

Inventor： Hong Liang TEY ,  Ruchir SRIVASTAVA ,  Ai Ping YOW ,  Jun CHENG ,  Annan LI ,  Wing Kee Damon WONG ,  Jiang LIU ,  Carolin WALL

IPC: A61B5/00 ,  G06T7/162 ,  G06T7/12 ,  G06T7/00

Abstract: The present disclosure generally relates to an automated method and system for generating a three-dimensional (3D) representation of a skin structure of a subject. The method comprises: acquiring a plurality of two-dimensional (2D) cross-sectional images of the skin structure, specifically, using optical coherence tomography (OCT) technique; computing a cost for each 2D cross-sectional image based on a cost function, the cost function comprising an edge-based parameter and a non-edge-based parameter; constructing a 3D graph from the 2D cross-sectional images; and determining a minimum-cost closed set from the 3D graph based on the computed costs for the 2D cross-sectional images, wherein the 3D representation of the skin structure is generated from the minimum-cost closed set.

公开(公告)号：US20170319059A1

公开(公告)日：2017-11-09

申请号：US15528080

申请日：2015-11-19

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  KABUSHIKI KAISHA TOPCON

Inventor： Jun CHENG ,  Jiang LIU ,  Wing Kee WONG ,  Masahiro AKIBA

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/00

CPC classification number: A61B3/102 ,  A61B3/0025 ,  G01B9/02082 ,  G01B9/02083 ,  G01B9/02091 ,  G06T5/002 ,  G06T5/50 ,  G06T2207/10101

Abstract: An optical coherence tomography (OCT) image composed of a plurality of A-scans of a structure is analysed by defining, for each A-scan, a set of neighbouring A-scans surrounding the A-slices scan. Following an optional de-noising step, the neighbouring A-scans are aligned in the imaging direction, then a matrix X is formed from the aligned A-scans, and matrix completion is performed to obtain a reduced speckle noise image.

公开(公告)号：US20170131082A1

公开(公告)日：2017-05-11

申请号：US15319360

申请日：2015-06-16

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  KABUSHIKI KAISHA TOPCON

Inventor： Jun CHENG ,  Jiang LIU ,  Lixin DUAN ,  Yanwu XU ,  Wing Kee Damon WONG ,  Masahiro AKIBA

IPC: G01B9/02 ,  G06T5/20 ,  G06T5/00 ,  G06T7/33 ,  A61B3/10 ,  G06T7/00

CPC classification number: G01B9/02082 ,  A61B3/102 ,  G01B9/02091 ,  G06T5/002 ,  G06T5/20 ,  G06T5/50 ,  G06T7/0014 ,  G06T7/32 ,  G06T7/337 ,  G06T2207/10016 ,  G06T2207/10101 ,  G06T2207/20021 ,  G06T2207/20024 ,  G06T2207/20221 ,  G06T2207/30041

Abstract: A method and system are proposed to obtain a reduced speckle noise image of a subject from optical coherence tomography (OCT) image data of the subject. The cross sectional images each comprise a plurality of scan lines obtained by measuring the time delay of light reflected, in a depth direction, from optical interfaces within the subject. The method comprises two aligning steps. First the cross sectional images are aligned, then image patches of the aligned cross sectional images are aligned to form a set of aligned patches. An image matrix is then formed from the aligned patches; and matrix completion is applied to the image matrix to obtain a reduced speckle noise image of the subject.

公开(公告)号：US20150363930A1

公开(公告)日：2015-12-17

申请号：US14762793

申请日：2014-01-22

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yanwu XU ,  Jiang LIU ,  Jun CHENG ,  Fengshou YIN ,  Wing Kee Damon WONG

IPC: G06T7/00 ,  G06K9/46 ,  G06K9/52 ,  G06K9/62

CPC classification number: G06T7/0014 ,  G06K9/46 ,  G06K9/52 ,  G06K9/6215 ,  G06K2009/4666 ,  G06T7/11 ,  G06T2207/30041

Abstract: A method is presented to obtain, from a retinal image, data characterizing the optic cup, such as data indicating the location and/or size of the optic cup in relation to the optic disc. A disc region of the retinal image of an eye, is expressed as a weighted sum of a plurality of pre-existing “reference” retinal images in a library, with the weights being chosen to minimize a cost function. The data characterizing the cup of the eye is obtained from cup data associated with the pre-existing disc images and the corresponding weights. The cost function includes (i) a construction error term indicating a difference between the disc region of the retinal image and a weighted sum of the reference retinal images, and (ii) a cost term, which may be generated using a weighted sum over the reference retinal images of a difference between the reference retinal images and the disc region of the retinal image.

Abstract translation: 呈现一种从视网膜图像获得表征视觉杯的数据的方法，诸如指示视觉杯相对于视盘的位置和/或尺寸的数据。 眼睛的视网膜图像的光盘区域被表示为图书馆中多个预先存在的“参考”视网膜图像的加权和，其中权重被选择以最小化成本函数。 表征眼睛杯的数据从与先前存在的光盘图像相关联的杯数据和相应的权重获得。 成本函数包括（i）指示视网膜图像的光盘区域与参考视网膜图像的加权和之间的差异的构造误差项，以及（ii）成本项，其可以使用加权和 参考视网膜图像与视网膜图像的光盘区域之间的差异的视网膜图像。