公开(公告)号：US20230320707A1

公开(公告)日：2023-10-12

申请号：US17926714

申请日：2021-06-11

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Kun Liang ,  Kit Mun Cheryl Leong

IPC: A61B10/02 ,  B29C33/42 ,  B33Y80/00

CPC classification number: A61B10/0233 ,  B33Y80/00 ,  B29C33/42

Abstract: The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, in one embodiment, the microneedles comprise a cone shape that is substantially devoid of patterning on the surface of said cone shape, in another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, in one embodiment, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

公开(公告)号：US20170258757A1

公开(公告)日：2017-09-14

申请号：US15598407

申请日：2017-05-18

Applicant: Agency for Science, Technology and Research

Inventor： Motoichi Kurisawa ,  Kun Liang ,  Susi Tan ,  Joo Eun Chung ,  Jackie Y. Ying

IPC: A61K31/282 ,  A61K9/107 ,  A61K31/353 ,  A61K31/704 ,  A61K31/7088 ,  A61K45/06 ,  A61K9/00 ,  A61K31/337

CPC classification number: A61K31/282 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/337 ,  A61K31/353 ,  A61K31/704 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/60 ,  A61K2300/00

Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.