公开(公告)号：US20160000757A1

公开(公告)日：2016-01-07

申请号：US14789928

申请日：2015-07-01

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lang Zhuo ,  Chunyan Zhang ,  Yugen Zhang ,  Jackie Y. Ying ,  Began Gopalan ,  Zhiyuan Ke ,  Zhaobing Ding

IPC: A61K31/4178

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/439 ,  A61K31/4439 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D235/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22

Abstract: There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium compounds as described herein, including imidazolium and imidazolinium salts.

Abstract translation: 目前提供了将抗纤维化或抗癌剂递送至细胞的方法。 所述方法包括使细胞与本文所述的有效量的咪唑鎓和咪唑啉化合物接触，包括咪唑鎓和咪唑啉鎓盐。

公开(公告)号：US20160331727A9

公开(公告)日：2016-11-17

申请号：US14789928

申请日：2015-07-01

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lang Zhuo ,  Chunyan Zhang ,  Yugen Zhang ,  Jackie Y. Ying ,  Began Gopalan ,  Zhiyuan Ke ,  Zhaobing Ding

IPC: A61K31/4178

CPC classification number: A61K31/4178 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/439 ,  A61K31/4439 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D235/06 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22

Abstract: There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium compounds as described herein, including imidazolium and imidazolinium salts.

公开(公告)号：US20140024038A1

公开(公告)日：2014-01-23

申请号：US13949143

申请日：2013-07-23

Applicant: Agency for Science, Technology and Research

Inventor： Gunter Maubach ,  Lang Zhuo ,  Michelle Chin Chia Lim

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  G01N33/5067 ,  G01N2333/96466 ,  G01N2500/10 ,  G01N2800/085

Abstract: The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.

Abstract translation: 本发明涉及用于鉴定抗纤维化或抗炎剂的方法，其包括测定暴露于测试化合物的活化肝星形细胞中的组织蛋白酶S表达，并将表达与未暴露的肝星状细胞进行比较。 本发明还涉及用于治疗由肝纤维化或炎症表征或引起的病症的方法，包括向受试者施用组织蛋白酶S抑制剂。