METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION
    3.
    发明申请
    METHOD AND REAGENTS FOR TREATING HEPATIC FIBROSIS AND INFLAMMATION 审中-公开
    治疗肝硬化和炎症的方法和试剂

    公开(公告)号:US20140024038A1

    公开(公告)日:2014-01-23

    申请号:US13949143

    申请日:2013-07-23

    Abstract: The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.

    Abstract translation: 本发明涉及用于鉴定抗纤维化或抗炎剂的方法,其包括测定暴露于测试化合物的活化肝星形细胞中的组织蛋白酶S表达,并将表达与未暴露的肝星状细胞进行比较。 本发明还涉及用于治疗由肝纤维化或炎症表征或引起的病症的方法,包括向受试者施用组织蛋白酶S抑制剂。

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