公开(公告)号：US20140024038A1

公开(公告)日：2014-01-23

申请号：US13949143

申请日：2013-07-23

Applicant: Agency for Science, Technology and Research

Inventor： Gunter Maubach ,  Lang Zhuo ,  Michelle Chin Chia Lim

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  G01N33/5067 ,  G01N2333/96466 ,  G01N2500/10 ,  G01N2800/085

Abstract: The invention relates to methods for identifying an anti-fibrotic or anti-inflammatory agent comprising determining cathepsin S expression in activated hepatic stellate cells which have been exposed to a test compound and comparing expression to non-exposed hepatic stellate cells. The invention also relates to methods for treating a disorder characterised or caused by hepatic fibrosis or inflammation, comprising administering a cathepsin S inhibitor to a subject.

Abstract translation: 本发明涉及用于鉴定抗纤维化或抗炎剂的方法，其包括测定暴露于测试化合物的活化肝星形细胞中的组织蛋白酶S表达，并将表达与未暴露的肝星状细胞进行比较。 本发明还涉及用于治疗由肝纤维化或炎症表征或引起的病症的方法，包括向受试者施用组织蛋白酶S抑制剂。

公开(公告)号：US20130268060A1

公开(公告)日：2013-10-10

申请号：US13917269

申请日：2013-06-13

Applicant: Agency for Science, Technology and Research

Inventor： Karl M. Schumacher ,  Jackie Y. Ying ,  Annegret Schumacher ,  Karthikeyan Narayanan ,  Gunter Maubach

IPC: C12N5/071 ,  A61F2/06

CPC classification number: C12N5/0686 ,  A61F2/06 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2506/02

Abstract: The present invention relates to methods of differentiating a human embryonic stem (ES) cell into a cell, specifically a renal epithelial cell, expressing AQP-I. The methods disclosed comprise culturing human ES cells in a renal specific medium in the presence of an extracellular matrix molecule. The cells produced according to said method can be used to treat renal related disorders such as renal failure, nephrosis, Bright's disease and glomerulitis.

Abstract translation: 本发明涉及将人胚胎干（ES）细胞分化成表达AQP-1的细胞，特别是肾上皮细胞的方法。 所公开的方法包括在细胞外基质分子的存在下在肾特异性培养基中培养人ES细胞。 根据所述方法产生的细胞可用于治疗肾脏相关疾病如肾衰竭，肾病，光明病和肾小球炎。