公开(公告)号：US10392443B2

公开(公告)日：2019-08-27

申请号：US15315597

申请日：2015-06-02

Applicant: Agency for Science, Technology and Research

Inventor： Sayan Chakraborty ,  Wanjin Hong

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/18 ,  A61K31/7105 ,  A61K31/713 ,  G01N33/574 ,  C07K16/32 ,  C12N15/113

Abstract: Disclosed is a method for determining the likelihood of the presence or progression of a hepatocellular carcinoma in a subject, comprising determining the level of extracellular form of Agrin in an extracellular fluid obtained from the subject. Also disclosed are the use of anti Agrin agent for therapy, a pharmaceutical composition comprising anti-Agrin agent, a method of treating cancer comprising an anti-Agrin agent, a use of anti-Agrin agent and a kit thereof.

公开(公告)号：US20230257435A1

公开(公告)日：2023-08-17

申请号：US18014449

申请日：2021-06-23

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Sayan Chakraborty ,  Wanjin Hong

IPC: C07K14/47 ,  A61P17/02

CPC classification number: C07K14/4725 ,  A61P17/02 ,  A61K38/00

Abstract: The present disclosure provides a pharmaceutical composition comprising an Agrin fragment or derivative thereof, and uses of the pharmaceutical composition. The present disclosure also provides method of producing the pharmaceutical composition.

公开(公告)号：US20170198055A1

公开(公告)日：2017-07-13

申请号：US15315597

申请日：2015-06-02

Applicant: Agency for Science, Technology and Research

Inventor： Sayan Chakraborty ,  Wanjin Hong

IPC: C07K16/30 ,  G01N33/574 ,  C07K16/32 ,  C12N15/113

CPC classification number: C07K16/303 ,  A61K31/7105 ,  A61K31/713 ,  C07K16/18 ,  C07K16/3015 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/77 ,  C12N15/1135 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/57415 ,  G01N33/57438 ,  G01N2333/4722

Abstract: Disclosed is a method for determining the likelihood of the presence or progression of a hepatocellular carcinoma in a subject, comprising determining the level of extracellular form of Agrin in an extracellular fluid obtained from the subject. Also disclosed are the use of anti Agrin agent for therapy, a pharmaceutical composition comprising anti-Agrin agent, a method of treating cancer comprising an anti-Agrin agent, a use of anti-Agrin agent and a kit thereof.