公开(公告)号：US20240159672A1

公开(公告)日：2024-05-16

申请号：US18549631

申请日：2022-03-14

Applicant: Agilent Technologies, Inc.

Inventor： Robert C. Taber

IPC: G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6408 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2021/7786

Abstract: A system and process is disclosed for measuring a fluorophore in a sample, such as a sample of a biological material. The process and system is particularly well suited to measuring fluorescent lifetimes of many different biological parameters. The system includes a time-of-flight sensor that can operate at a modulation rate capable of measuring fluorescent lifetimes that are extremely short, such as lasting only a few nanoseconds. Although the system and process have broad applicability, the system and process are particularly well suited for measuring metabolic characteristics of cells, such as pH, oxygen, and temperature.

公开(公告)号：US09341516B2

公开(公告)日：2016-05-17

申请号：US14015529

申请日：2013-08-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Miao Zhu ,  Adam Kleczewski ,  Robert C. Taber

IPC: G01B9/02 ,  G01J3/45 ,  G01J3/453

CPC classification number: G01J3/45 ,  G01J3/453 ,  G01J3/4535

Abstract: A system for performing optical spectroscopy measurements includes a light source for generating an input optical beam and an interferometer. The interferometer includes a beam splitter that splits the input optical beam into first and second light beams; a first light path that directs the first light beam through a sample containing an analyte to a first output port; and a second light path that directs the second light beam to the first output port. At least one of the first and second light paths adjusts a relative phase of a corresponding one of the first and second light beams, so that the first and second light beams are out of phase at the first output port, substantially canceling background light and outputting sample light corresponding to a portion of the first light signal absorbed by the sample in the sample cell. A detection system detects the output sample light.

Abstract translation: 用于执行光谱测量的系统包括用于产生输入光束的光源和干涉仪。 干涉仪包括分束器，其将输入光束分成第一和第二光束; 将第一光束通过含有分析物的样品引导到第一输出端口的第一光路; 以及将第二光束引导到第一输出端口的第二光路。 第一和第二光路中的至少一个光路调节第一和第二光束中的相应一个的相对相位，使得第一和第二光束在第一输出端口处异相，基本上消除背景光并输出 对应于样品池中由样品吸收的第一光信号的一部分的样品光。 检测系统检测输出样品光。

公开(公告)号：US20150062586A1

公开(公告)日：2015-03-05

申请号：US14015529

申请日：2013-08-30

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Miao Zhu ,  Adam Kleczewski ,  Robert C. Taber

IPC: G01J3/45

CPC classification number: G01J3/45 ,  G01J3/453 ,  G01J3/4535

Abstract: A system for performing optical spectroscopy measurements includes a light source for generating an input optical beam and an interferometer. The interferometer includes a beam splitter that splits the input optical beam into first and second light beams; a first light path that directs the first light beam through a sample containing an analyte to a first output port; and a second light path that directs the second light beam to the first output port. At least one of the first and second light paths adjusts a relative phase of a corresponding one of the first and second light beams, so that the first and second light beams are out of phase at the first output port, substantially canceling background light and outputting sample light corresponding to a portion of the first light signal absorbed by the sample in the sample cell. A detection system detects the output sample light.

Abstract translation: 用于执行光谱测量的系统包括用于产生输入光束的光源和干涉仪。 干涉仪包括分束器，其将输入光束分成第一和第二光束; 将第一光束通过含有分析物的样品引导到第一输出端口的第一光路; 以及将第二光束引导到第一输出端口的第二光路。 第一和第二光路中的至少一个光路调节第一和第二光束中的相应一个的相对相位，使得第一和第二光束在第一输出端口处异相，基本上消除背景光并输出 对应于样品池中由样品吸收的第一光信号的一部分的样品光。 检测系统检测输出样品光。