CHITOSAN DENTAL SURGICAL MEMBRANE AND METHOD OF MAKING
    1.
    发明申请
    CHITOSAN DENTAL SURGICAL MEMBRANE AND METHOD OF MAKING 审中-公开
    CHITOSAN牙科手术膜及其制备方法

    公开(公告)号:US20140314825A1

    公开(公告)日:2014-10-23

    申请号:US14359254

    申请日:2012-11-20

    CPC classification number: A61L31/146 A61L31/042 A61L2430/12 C08L5/08

    Abstract: A porous, resorbable and flexible dental surgical membrane (16) is made from chitosan having a molecular weight of at least 400,000 daltons and has a thickness of from about 100 microns to about 0.5 mm. The membrane is easily insertable over a bone graft material site to confine the bone graft material (14) while allowing access to it of blood and oxygen. The high molecular weight of the chitosan may be chosen so that the membrane will not dissolve or resorb in a human mouth for a protracted period, e.g., from about 12 to about 16 weeks. The membrane is made by dissolving medical grade chitosan in aqueous acetic acid, dispersing fine silica particles into the solution to form a slurry, depositing a film of the slurry on a support surface, evaporating liquid from the slurry sufficiently to form a coherent chitosan membrane having silica particles dispersed therein, and then dissolving the silica particles with a sodium hydroxide solution followed by a water wash to form the porous chitosan membrane.

    Abstract translation: 多孔,可吸收和灵活的牙科手术膜(16)由分子量至少为400,000道尔顿的壳聚糖制成,具有约100微米至约0.5毫米的厚度。 膜易于插入骨移植材料部位以限制骨移植材料(14),同时允许其接触血液和氧气。 可以选择壳聚糖的高分子量,使得膜不会溶解或吸收在人口中持续持续的时间,例如约12至约16周。 该膜通过将医用级脱乙酰壳多糖溶解在乙酸水溶液中,将二氧化硅微粒分散到溶液中以形成浆料,将浆料膜沉积在支撑表面上,充分蒸发浆液中的液体以形成粘性的壳聚糖膜, 分散在其中的二氧化硅颗粒,然后用氢氧化钠溶液溶解二氧化硅颗粒,随后进行水洗以形成多孔壳聚糖膜。

    CHITOSAN DENTAL SURGICAL MEMBRANE AND METHOD OF MAKING

    公开(公告)号:US20170224868A1

    公开(公告)日:2017-08-10

    申请号:US15332770

    申请日:2016-10-24

    Abstract: A porous, resorbable and flexible dental surgical membrane (16) is made from chitosan having a viscosity average molecular weight of about 400,000 daltons up to about 2,000,000 daltons and has a thickness of from about 100 microns to about 0.5 mm. The membrane is easily insertable over a bone graft material site to confine the bone graft material (14) while allowing access to the bone graft material of blood and oxygen and applied medicaments through the membrane. The high molecular weight of the chitosan may be chosen so that the membrane will not dissolve or resorb in a human mouth for a protracted period, e.g., from about 12 to about 16 weeks. The membrane is made by dissolving medical grade chitosan in aqueous acetic acid, dispersing fine silica particles into the solution to form a slurry, depositing a film of the slurry on a support surface, evaporating liquid from the slurry sufficiently to form a coherent chitosan membrane having silica particles dispersed therein, and then dissolving the silica particles with a sodium hydroxide solution followed by a water wash to form the porous chitosan membrane.

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