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    Injectable silk fibroin foams and uses thereof
    5.
    发明授权
    Injectable silk fibroin foams and uses thereof 有权
    可注射的丝素蛋白泡沫及其用途

    公开(公告)号：US09492504B2

    公开(公告)日：2016-11-15

    申请号：US14357420

    申请日：2012-11-09

    申请人： Trustees of Tufts College

    发明人： Gary G. Leisk ,  Tim Jia-Ching Lo ,  Lei Li ,  Evangelia Bellas ,  David L. Kaplan

    IPC分类号： A61K35/12 ,  A61L27/56 ,  A61K47/42 ,  A61K38/17 ,  A61L27/22 ,  A61L27/36 ,  A61L27/38 ,  A61L27/48 ,  A61L27/54

    CPC分类号： A61L27/227 ,  A61K38/1767 ,  A61L27/3604 ,  A61L27/3834 ,  A61L27/48 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2400/08 ,  A61L2430/34 ,  C08L89/00

    摘要： The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.

    摘要翻译： 本文提供的发明涉及用于修复或增加受试者中的组织的组合物，方法，递送装置和试剂盒。 本文描述的组合物可以是可注射的，使得它们可以以微创程序（例如通过注射）置于待治疗的组织中。 在一些实施方案中，本文所述的组合物包含压缩的丝素蛋白基质，其可以在注射到组织中时膨胀并且将其初始膨胀体积保持在组织内一段时间。 组合物可以用作填充剂以代替组织空隙，例如用于组织修复和/或增加，或作为支架以支持组织再生和/或重建。 在一些实施方案中，本文所述的组合物可用于软组织修复或增强。

    ph-sensitive sacrificial materials for the microfabrication of structures
    7.
    发明授权
    ph-sensitive sacrificial materials for the microfabrication of structures 有权
    用于微结构结构的ph敏感牺牲材料

    公开(公告)号：US09458357B2

    公开(公告)日：2016-10-04

    申请号：US13410600

    申请日：2012-03-02

    申请人： Leon M. Bellan ,  Robert S. Langer ,  Donald M. Cropek

    发明人： Leon M. Bellan ,  Robert S. Langer ,  Donald M. Cropek

    IPC分类号： C09F1/04 ,  C09D193/02 ,  A61L27/14 ,  A61L27/56 ,  C09D189/06

    CPC分类号： C09F1/04 ,  A61L27/14 ,  A61L27/56 ,  A61L2400/08 ,  C09D189/06 ,  C09D193/02

    摘要： Methods for microfabricating composite materials and composite materials prepared there from are described herein. The sacrificial material can be etched or patterned to create a two-dimensional and/or three-dimensional sacrificial material structure. The resulting sacrificial material structure can be embedded in one or more embedding materials. The sacrificial material(s) are materials whose solubility can be altered by application of a stimulus typically pH, and/or temperature, light, pH, pressure, presence of absence of ions, and combinations thereof. The embedding materials can contain one or more additives that modify one or more properties of the embedding materials, such as degradation properties, porosity, mechanical properties, viscosity, conductive properties, and combinations thereof. The composite materials can be used in tissue engineering, drug screening, toxin detection, drug delivery, filtrations, bioseparations, and as microfluidic devices for fluid mixing and structural repair.

    摘要翻译： 本文描述了在此制备的复合材料和复合材料的微加工方法。 牺牲材料可以被蚀刻或图案化以产生二维和/或三维牺牲材料结构。 所得到的牺牲材料结构可嵌入一种或多种嵌入材料中。 牺牲材料是其溶解度可以通过施加通常为pH，和/或温度，光，pH，压力，不存在离子的组合和其组合而改变的材料。 嵌入材料可以包含一种或多种改性嵌入材料的一种或多种性质的添加剂，例如降解性能，孔隙率，机械性能，粘度，导电性能及其组合。 复合材料可用于组织工程，药物筛选，毒素检测，药物递送，过滤，生物分离和用作流体混合和结构修复的微流体装置。

    METHODS OF MANUFACTURING HYDROGEL MICROPARTICLES HAVING LIVING CELLS, AND COMPOSITIONS FOR MANUFACTURING A SCAFFOLD FOR TISSUE ENGINEERING
    10.
    发明申请
    METHODS OF MANUFACTURING HYDROGEL MICROPARTICLES HAVING LIVING CELLS, AND COMPOSITIONS FOR MANUFACTURING A SCAFFOLD FOR TISSUE ENGINEERING 有权
    生产生物细胞的水凝胶微生物的制备方法以及用于制造组织工程用SCAFFOLD的组合物

    公开(公告)号：US20150217024A1

    公开(公告)日：2015-08-06

    申请号：US14420278

    申请日：2013-07-26

    申请人： Nanyang Technological University

    发明人： Dongan Wang ,  Ting Ting Lau ,  Wen Yan Leong

    IPC分类号： A61L27/52 ,  A61L27/22 ,  A61L27/38

    CPC分类号： A61L27/52 ,  A61L27/14 ,  A61L27/222 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/56 ,  A61L2400/06 ,  A61L2400/08 ,  A61L2430/00 ,  A61L2430/06

    摘要： Method of manufacturing hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein is provided. The method includes dissolving a hydrogel-forming agent in an aqueous medium to form a solution; suspending one or more species of living cells in the solution to form a cell suspension; dispersing the cell suspension into an organic oil to form a microemulsion; and subjecting the microemulsion to conditions that allow the hydrogel-forming agent to form hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein. Composition comprising a mixture of a degradable hydrogel and at least one hydrogel microparticle having one or more species of living cells, and method of manufacturing a scaffold for tissue engineering are also provided.

    摘要翻译： 提供制造包含一种或多种附着在其上和/或包封的活细胞的水凝胶微粒的方法。 该方法包括将水凝胶形成剂溶解在水性介质中以形成溶液; 将一种或多种活细胞悬浮在溶液中以形成细胞悬浮液; 将细胞悬浮液分散到有机油中以形成微乳液; 并使微乳液经受允许水凝胶形成剂形成包含一种或多种附着在其上和/或包封的活细胞种类的水凝胶微粒的条件。 还提供了包含可降解水凝胶和至少一种具有一种或多种活细胞种类的水凝胶微粒的混合物的组合物，以及组织工程用支架的制造方法。