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公开(公告)号：US11957688B2
公开(公告)日：2024-04-16
申请号：US17862471
申请日：2022-07-12
IPC分类号： A61K31/5375 , A61K9/00 , A61K31/4152 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/66 , A61K31/675 , A61K45/06 , A61P25/00 , A61P25/08 , A61P25/28
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/428 , A61K45/06 , A61P25/00 , A61P25/08 , A61P25/28 , A61K31/5377 , A61K2300/00
摘要： Provided are compositions and methods related to the use of apilimod in combination with glutamatergic agents for treating neurological diseases and disorders, and for the treatment of cancer.
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公开(公告)号：US11439649B2
公开(公告)日：2022-09-13
申请号：US16987542
申请日：2020-08-07
IPC分类号： A61K31/5375 , A61K31/675 , A61K31/66 , A61K31/498 , A61K31/4152 , A61K31/5377 , A61P25/00 , A61K9/00 , A61K31/428 , A61P25/28 , A61K45/06 , A61P25/08
摘要： Provided are compositions and methods related to the use of apilimod in combination with glutamatergic agents for treating neurological diseases and disorders, and for the treatment of cancer.
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公开(公告)号：US11266654B2
公开(公告)日：2022-03-08
申请号：US16728566
申请日：2019-12-27
发明人： Henri Lichenstein , Jonathan M. Rothberg , Sophia Gayle , Neil Beeharry , Paul Beckett , Sean Landrette , Chris Conrad , Matt Dyer , Tian Xu
IPC分类号： A61K31/5377 , A61K31/44 , A61K31/506 , A61K31/404 , A61K31/4178 , A61K31/475 , A61K31/573 , A61K31/704 , A61K45/06 , A61K9/00 , A61K31/436 , A61K31/519 , A61K31/675 , A61K31/69
摘要： The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
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公开(公告)号：US10799508B2
公开(公告)日：2020-10-13
申请号：US15885975
申请日：2018-02-01
发明人： Neil Beeharry , Marylens Hernandez , Sean Landrette , Tian Xu , Jonathan M. Rothberg , Henri Lichenstein
IPC分类号： A61K31/52 , A61K31/496 , A61K31/437 , A61K31/46 , A61P35/02 , A61K31/416 , A61P35/00 , A61K31/444 , A61K31/635 , A61K31/395 , A61K45/06
摘要： The disclosure also provides compositions and methods related to combination therapy with HSP90 inhibitors and BCL-2 pathway inhibitors for treating cancer. The disclosure also provides compositions and methods related to the use of ‘low dose’ HSP90 inhibitors in the treatment of cancer, alone and in combination with other therapeutic agents.
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公开(公告)号：US20240189317A1
公开(公告)日：2024-06-13
申请号：US18281942
申请日：2022-03-15
发明人： Peter R. Young , Sean Landrette , Carlo Spirli , Keith Fandrick , Murat Gunel
IPC分类号： A61K31/5377 , A61K31/245 , A61P31/12
CPC分类号： A61K31/5377 , A61K31/245 , A61P31/12
摘要： The present invention relates to compositions and related methods of using a PIKfyve inhibitor, such as apilimod, in combination with a serine protease inhibitor, for treating or preventing viral disease.
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公开(公告)号：US20230069069A1
公开(公告)日：2023-03-02
申请号：US17862471
申请日：2022-07-12
IPC分类号： A61K31/5377 , A61P25/00 , A61K9/00 , A61K31/428 , A61P25/28 , A61K45/06 , A61P25/08
摘要： Provided are compositions and methods related to the use of apilimod in combination with glutamatergic agents for treating neurological diseases and disorders, and for the treatment of cancer.
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公开(公告)号：US10751345B2
公开(公告)日：2020-08-25
申请号：US16280106
申请日：2019-02-20
IPC分类号： A61K31/5375 , A61K31/675 , A61K31/66 , A61K31/498 , A61K31/5377 , A61P25/00 , A61K9/00 , A61K31/428 , A61P25/28 , A61K45/06 , A61P25/08
摘要： Provided are compositions and methods related to the use of apilimod in combination with glutamatergic agents for treating neurological diseases and disorders, and for the treatment of cancer.
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公开(公告)号：US10729694B2
公开(公告)日：2020-08-04
申请号：US15545337
申请日：2016-01-21
发明人： Henri Lichenstein , Jonathan M. Rothberg , Neil Beeharry , Paul Beckett , Sean Landrette , Chris Conrad
IPC分类号： A61K31/5377 , A61K31/00 , A61K38/21 , A61K45/06 , A61K31/713 , A61K39/395 , C07K16/10 , C12N15/113
摘要： The present invention relates to compositions containing a PIKfyve inhibitor, preferably apilimod, APY0201 or YM-201636, most preferably apilimod, for use in treating or preventing viral infections, preferably Ebola or Marburg virus infections. It also relates to a pharmaceutical pack or kit comprising apillimod and at least one additional anti-viral agent.
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公开(公告)号：US10350213B2
公开(公告)日：2019-07-16
申请号：US15213829
申请日：2016-07-19
发明人： Henri Lichenstein , Jonathan M. Rothberg , Sophia Gayle , Neil Beeharry , Paul Beckett , Sean Landrette , Chris Conrad , Tian Xu
IPC分类号： A61K31/5377 , A61K31/506 , A61K45/06 , A61K31/454 , A61K31/4745 , A61K31/519 , A61K31/573 , A61K31/664 , A61K31/704 , A61K31/44
摘要： The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
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公开(公告)号：US20200268764A1
公开(公告)日：2020-08-27
申请号：US16728566
申请日：2019-12-27
发明人： Henri Lichenstein , Jonathan M. Rothberg , Sophia Gayle , Neil Beeharry , Paul Beckett , Sean Landrette , Chris Conrad , Matt Dyer , Tian Xu
IPC分类号： A61K31/5377 , A61K31/404 , A61K31/4178 , A61K31/475 , A61K31/573 , A61K31/704 , A61K45/06 , A61K31/44 , A61K31/506 , A61K9/00 , A61K31/436 , A61K31/519 , A61K31/675 , A61K31/69
摘要： The present invention relates to methods for treating cancer with apilimod and related compositions and methods.
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