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公开(公告)号:US20130288992A1
公开(公告)日:2013-10-31
申请号:US13923881
申请日:2013-06-21
Applicant: AJINOMOTO CO., INC.
Inventor: Wataru KUROSAWA , Takuya Toyoda , Risa Ubagai , Yoshihito Nogusa , Kana Oyama , Yusuke Amino
IPC: C07H15/207 , C12P19/46
CPC classification number: C07H15/207 , A23L33/10 , C07H15/203 , C12P19/46
Abstract: Compounds of formula (I″) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue, X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH═CH—CH2—, X2 is —CO—O— or —O—CO—, p and q are integer ofs 0 to 7, and p+q=0 to 8, Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and R16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.
Abstract translation: 式(I“)的化合物其中:R 11,R 12,R 13,R 14和R 15是氢,羟基,C 1-6烷基,C 1-6烷氧基,C 1-6烷基 - 羰基氧基或GO-基团,至少 R11,R12,R13,R14和R15之一是GO-基团,其中G是糖残基,X1是单键,或亚甲基,亚乙基,三亚甲基,亚乙烯基或-CH = CH-CH 2 - ,X 2是-CO-O-或-O-CO-,p和q是0〜7的整数,p + q = 0〜8,Y 1是亚甲基,亚乙基或具有碳的亚烯基 2至15个和1至3个双键,R16和R17是氢,甲基或乙基,或R16和R17形成C3-6环烷基,可用作GLP-1分泌促进剂。