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    New fungal strain acremonium sp.mt70646(kctc 8973p) novel compounds produced by this strain and their use
    9.
    发明申请
    New fungal strain acremonium sp.mt70646(kctc 8973p) novel compounds produced by this strain and their use 失效
    新霉菌菌株sp.mt70646（kctc 8973p）由该菌株产生的新化合物及其用途

    公开(公告)号：US20030032603A1

    公开(公告)日：2003-02-13

    申请号：US10168807

    申请日：2002-06-21

    发明人： Jong Seog Ahn ,  Bo Yeon Kim ,  Won Keun Oh ,  Tae Ick Mheen ,  Soon Cheol Ahn ,  Dae Ook Kang ,  Hack Ryong Ko ,  Hwan Mook Kim

    IPC分类号： A61K031/7034 ,  C12N001/16 ,  C07H015/04

    CPC分类号： C07H15/203 ,  C12P19/46 ,  C12R1/645

    摘要： The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC 8973P) was isolated from the soil. From the culture of the isolated fungal strain, novel compounds that can inhibit both heparinase and heparanase was purified. Therefore, the present invention regards to provide a newly isolated fungal strain Acremonium sp. MT70646 (KCTC 8973P), its new products, and pharmaceutical agents such as a heparinase inhibitor, a heparanase inhibitor, a metastasis inhibitor and an angeiogenesis inhibitor all of which contain the above new compounds produced by the fungal strain as an active ingredient.

    摘要翻译： 本发明旨在发现能够对乙酰肝素酶发挥优异抑制活性的新型抗癌化合物。 真菌菌株Acremonium sp。 从土壤中分离出MT70646（KCTC8973P）。 从分离的真菌菌株的培养物中纯化可抑制肝素酶和乙酰肝素酶的新型化合物。 因此，本发明提供了一种新分离的真菌菌株Acremonium sp。 MT70646（KCTC8973P）及其新产品，以及诸如肝素酶抑制剂，乙酰肝素酶抑制剂，转移抑制剂和血管发生抑制剂等药剂，均含有上述由真菌菌株生产的新化合物作为活性成分。

    Sophoroselipids, method for their production and use
    10.
    发明授权
    Sophoroselipids, method for their production and use 失效
    苦参皂甙，其生产和使用方法

    公开(公告)号：US06433152B1

    公开(公告)日：2002-08-13

    申请号：US09530769

    申请日：2000-07-03

    申请人： Siegmund Lang ,  Andreas Brakemeier ,  Dieter Wullbrandt ,  Andreas Seiffert-Störicko

    发明人： Siegmund Lang ,  Andreas Brakemeier ,  Dieter Wullbrandt ,  Andreas Seiffert-Störicko

    IPC分类号： C07G300

    CPC分类号： C11D1/667 ,  A01N43/16 ,  A61K8/602 ,  A61K2800/85 ,  A61Q19/00 ,  C07H15/04 ,  C12P19/46

    摘要： The invention relates to sophoroselipids of formula (I) wherein R4 represents H, —CH2CH3, —CH2CH2CH3, n is an integer number from 2 to 27, R1 and R2 represent, independently from each other, H or a group of formula (II), and R3 represents H or —OH. The invention also relates to a method for producing sophoroselipids of formula (I) wherein R1, R2, R3 and n have the aforementioned meanings and R4 represents —CH3, —CH2CH3 or —CH2CH2CH3. According to this method, a yeast capable of secreting a sophoroselipid in the form of a lactone in the culture excess, is fermented in a culture medium containing a glycerin. a succinate, a mono-, di- and/or tri-saccharide and a lipid precursor, said sophoroslipid being then isolated from the culture solution. The inventive method is characterised in that the lipid precursor contains one or more 3-alkanols, 4-alkanols or an alkanone with a chain length from 6 to 30 carbon atoms or mixtures of said alkanoistalkanone. Furthermore, according to a variant of the aforementioned method for producing sophoroselipids of formula (I), wherein R1, R2, R3 and n have the meanings aforementioned and R4 represents —CH3, —CH2CH3 or —CH2CH2CH3, the culture medium is maintained during fermentation under a reduced oxygen concentration. The new sophoroselipids may be used, e.g., as surfactants, cosmetics, disinfecting agents or pharmaceutical products.

    摘要翻译： 本发明涉及式（I）的槐糖脂，其中R 4表示H，-CH 2 CH 3，-CH 2 CH 2 CH 3，n是2至27的整数，R 1和R 2彼此独立地表示H或式（II）的基团， ，R 3表示H或-OH。 本发明还涉及制备式（I）的槐糖脂的方法，其中R 1，R 2，R 3和n具有上述含义，R 4表示-CH 3，-CH 2 CH 3或-CH 2 CH 2 CH 3。 根据该方法，将能够分泌培养过量的内酯形式的槐糖脂的酵母在含有甘油的培养基中发酵。 琥珀酸盐，单糖，二糖和/或三糖和脂质前体，然后从培养溶液中分离出所述槐糖脂。 本发明的方法的特征在于脂质前体含有一个或多个3-链烷醇，4-链烷醇或链长为6-30个碳原子的烷酮或所述烷酰基烷酮的混合物。 此外，根据上述制备式（I）的槐糖脂的方法的变体，其中R1，R2，R3和n具有上述含义，R4代表-CH3，-CH2CH3或-CH2CH2CH3，培养基在发酵期间保持 在氧浓度降低的情况下。 可以使用新的槐糖脂，例如作为表面活性剂，化妆品，消毒剂或药物产品。