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    GLYCOSIDE COMPOUND
    4.
    发明申请
    GLYCOSIDE COMPOUND 有权
    甘氨酸化合物

    公开(公告)号：US20130288992A1

    公开(公告)日：2013-10-31

    申请号：US13923881

    申请日：2013-06-21

    Applicant: AJINOMOTO CO., INC.

    Inventor： Wataru KUROSAWA ,  Takuya Toyoda ,  Risa Ubagai ,  Yoshihito Nogusa ,  Kana Oyama ,  Yusuke Amino

    IPC: C07H15/207 ,  C12P19/46

    CPC classification number: C07H15/207 ,  A23L33/10 ,  C07H15/203 ,  C12P19/46

    Abstract: Compounds of formula (I″) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue, X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH═CH—CH2—, X2 is —CO—O— or —O—CO—, p and q are integer ofs 0 to 7, and p+q=0 to 8, Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and R16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.

    Abstract translation: 式（I“）的化合物其中：R 11，R 12，R 13，R 14和R 15是氢，羟基，C 1-6烷基，C 1-6烷氧基，C 1-6烷基 - 羰基氧基或GO-基团，至少 R11，R12，R13，R14和R15之一是GO-基团，其中G是糖残基，X1是单键，或亚甲基，亚乙基，三亚甲基，亚乙烯基或-CH = CH-CH 2 - ，X 2是-CO-O-或-O-CO-，p和q是0〜7的整数，p + q = 0〜8，Y 1是亚甲基，亚乙基或具有碳的亚烯基 2至15个和1至3个双键，R16和R17是氢，甲基或乙基，或R16和R17形成C3-6环烷基，可用作GLP-1分泌促进剂。

    Glycoside compound
    5.
    发明授权
    Glycoside compound 有权
    糖苷化合物

    公开(公告)号：US09175028B2

    公开(公告)日：2015-11-03

    申请号：US13923881

    申请日：2013-06-21

    Applicant: AJINOMOTO CO., INC.

    Inventor： Wataru Kurosawa ,  Takuya Toyoda ,  Risa Ubagai ,  Yoshihito Nogusa ,  Kana Ohyama ,  Yusuke Amino

    IPC: C07H15/207 ,  C12P19/46 ,  A23L1/30 ,  C07H15/203

    CPC classification number: C07H15/207 ,  A23L33/10 ,  C07H15/203 ,  C12P19/46

    Abstract: Compounds of formula (I″) wherein: R11, R12, R13, R14 and R15 are hydrogen, hydroxyl, C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl-carbonyloxy, or a G-O— group, and at least one of R11, R12, R13, R14 and R15 is a G-O— group, wherein G is a saccharide residue, X1 is a single bond, or a methylene group, an ethylene group, a trimethylene group, a vinylene group or —CH═CH—CH2—, X2 is —CO—O— or —O—CO—, p and q are integer ofs 0 to 7, and p+q=0 to 8, Y1 is methylene, ethylene or an alkenylene group having a carbon number of 2 to 15 and 1 to 3 double bonds, and R16 and R17 are hydrogen, methyl or ethyl, or R16 and R17 form a C3-6 cycloalkyl group, are useful as GLP-1 secretion promoting agents.

    Abstract translation: 式（I“）的化合物其中：R 11，R 12，R 13，R 14和R 15是氢，羟基，C 1-6烷基，C 1-6烷氧基，C 1-6烷基 - 羰氧基或GO-基团，和至少一个 R11，R12，R13，R14和R15是GO-基团，其中G是糖残基，X1是单键或亚甲基，亚乙基，三亚甲基，亚乙烯基或-CH = CH -CH 2 - ，X 2是-CO-O-或-O-CO-，p和q是0〜7的整数，p + q = 0〜8，Y 1是亚甲基，亚乙基或具有碳数的亚烯基 2至15个和1至3个双键，R16和R17是氢，甲基或乙基，或R16和R17形成C3-6环烷基，可用作GLP-1分泌促进剂。

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