公开(公告)号：US20210278421A1

公开(公告)日：2021-09-09

申请号：US17212195

申请日：2021-03-25

Applicant: AJINOMOTO CO., INC.

Inventor： Takeshi IKEUCHI ,  Yuki YANO ,  Hiroko KONDO ,  Wataru SATO ,  Naoko ARASHIDA ,  Satoko UENO ,  Rumi NISHIMOTO ,  Masashi HARADA

IPC: G01N33/68 ,  G16H50/30

Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment for a subject to be evaluated, using (i) at least one value of concentration values of Put, α-ABA, Ala, Arg, Asn, Cit, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Taurine, 1-MeHis, 3-MeHis, aAAA, aAiBA, ADMA, Allyl Cys, bABA, bAiBA, Cystathionine, Cysteic acid, EtGly, GABA, hArg, Hypotaurine, Hypro, Kyn, Pyrazole-1-Ala, MCSO, MeCys, N6-AcLys, N8-AcSpd, Opthalmic acid, PEA, Pipecolic acid, Sar, SDMA, Spd, Spm, and Thioproline and test values of Alb, Folate, WBC, RBC, Hb, Ht, and PLT in blood of the subject, or (ii) a value of a formula including an explanatory variable to be substituted with the at least one value, calculated using the at least one value and the formula.

公开(公告)号：US20220267264A1

公开(公告)日：2022-08-25

申请号：US17700721

申请日：2022-03-22

Applicant: Ajinomoto Co., Inc.

Inventor： Masashi HARADA

IPC: C07C319/18 ,  C07D207/416 ,  C07C315/00 ,  C07C319/20 ,  G01N30/06

Abstract: Derivatives of an organic substance containing one or more groups selected from the group consisting of sulfanyl, selanyl and sulfino may be produced by reacting an organic substance containing one or more groups selected from the group consisting of sulfanyl, selanyl and sulfino with an olefin compound containing an ethylene structure having at least two electron-withdrawing groups except halogen atoms under an acidic condition to form a derivative of the organic substance