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公开(公告)号：US20190228844A1
公开(公告)日：2019-07-25
申请号：US16373427
申请日：2019-04-02
Applicant: AJINOMOTO CO., INC.
Inventor： Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI , Kazutaka SHIMBO , Naoko ARASHIDA , Rumi NISHIMOTO
IPC: G16C20/70
Abstract: An evaluating method includes an evaluating step of evaluating a state of colorectal cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of bABA, N-Me-bABA, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, GABA, Homoarginine, Hypotaurine, Kinurenine, N6-Acetyl-L-Lys, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, SDMA, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.
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公开(公告)号：US20250020656A1
公开(公告)日：2025-01-16
申请号：US18784141
申请日：2024-07-25
Applicant: AJINOMOTO CO., INC.
Inventor： Naoko ARASHIDA , Rumi NISHIMOTO , Kazutaka SHIMBO , Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI
IPC: G01N33/68 , G01N33/574 , G16H50/20
Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.
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Patent Agency Ranking
3.发明申请公开(公告)号：US20180017570A1
公开(公告)日：2018-01-18
申请号：US15715389
申请日：2017-09-26
Applicant: AJINOMOTO CO., INC.
Inventor： Naoko ARASHIDA , Rumi NISHIMOTO , Kazutaka SHIMBO , Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI
IPC: G01N33/68 , G01N33/574 , G06F19/00
CPC classification number: G01N33/6812 , G01N33/57423 , G01N2800/56 , G06F19/3418 , G16H50/20
Abstract: An evaluating method includes an evaluating step of evaluating a state of lung cancer for a subject to be evaluated using a concentration value of at least one of Homoarginine, GABA, 3-Me-His, ADMA, Spermine, Spermidine, Cystathionine, Sarcosine, aAiBA, bAiBA, Putrescine, N-Acetyl-L-lys, Hypotaurine, bABA, and Ethylglycine in blood of the subject.
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公开(公告)号：US20220268790A1
公开(公告)日：2022-08-25
申请号：US17730484
申请日：2022-04-27
Applicant: AJINOMOTO CO., INC.
Inventor： Sachise KARAKAWA , Tomoyuki TAGAMI , Rumi NISHIMOTO , Shinya KIKUCHI , Akira IMAIZUMI , Koichi AZUMA , Tomoaki HOSHINO , Takaaki TOKITO , Hidenobu ISHII , Norikazu MATSUO
Abstract: An evaluating method includes an evaluating step of evaluating a pharmacological action of an immune checkpoint inhibitor in a subject to be evaluated, using (i) a concentration value of at least one metabolite among Glu, Arg, Orn, Cit, His, Val, Phe, Tyr, Met, Pro, Asn, Leu, Lys, Thr, Ile, Gln, Ala, Ser, a-ABA, Trp, Gly, AnthA, hAnthA, hIAA, hKyn, hTrp, IAA, ILA, Kyn, KynA, NFKyn, NP, PA, QA, Serot, and XA in blood of the subject to be evaluated, or (ii) a value of a formula calculated using the concentration value and the formula including an explanatory variable to be substituted with the concentration value.
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公开(公告)号：US20210278421A1
公开(公告)日：2021-09-09
申请号：US17212195
申请日：2021-03-25
Applicant: AJINOMOTO CO., INC.
Inventor： Takeshi IKEUCHI , Yuki YANO , Hiroko KONDO , Wataru SATO , Naoko ARASHIDA , Satoko UENO , Rumi NISHIMOTO , Masashi HARADA
Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment for a subject to be evaluated, using (i) at least one value of concentration values of Put, α-ABA, Ala, Arg, Asn, Cit, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Taurine, 1-MeHis, 3-MeHis, aAAA, aAiBA, ADMA, Allyl Cys, bABA, bAiBA, Cystathionine, Cysteic acid, EtGly, GABA, hArg, Hypotaurine, Hypro, Kyn, Pyrazole-1-Ala, MCSO, MeCys, N6-AcLys, N8-AcSpd, Opthalmic acid, PEA, Pipecolic acid, Sar, SDMA, Spd, Spm, and Thioproline and test values of Alb, Folate, WBC, RBC, Hb, Ht, and PLT in blood of the subject, or (ii) a value of a formula including an explanatory variable to be substituted with the at least one value, calculated using the at least one value and the formula.
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公开(公告)号：US20190277862A1
公开(公告)日：2019-09-12
申请号：US16239817
申请日：2019-01-04
Applicant: AJINOMOTO CO., INC.
Inventor： Takeshi IKEUCHI , Nobuhiro KAWAI , Yuki YANO , Naoko ARASHIDA , Rumi NISHIMOTO , Kazutaka SHIMBO
IPC: G01N33/68
Abstract: An evaluating method includes an evaluating step of evaluating a state of mild cognitive impairment or Alzheimer's disease for a subject to be evaluated using a concentration value of at least one of α-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, GABA, Hypotaurine, S-Adenosyl homocysteine, Sarcosine, Serotonin, Spermidine, hCit, 3-hKyn, aAiBA, N8-Acetylspermidine, Phosphoserine, bABA, ADMA, and Thioproline in blood of the subject.
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公开(公告)号：US20190227071A1
公开(公告)日：2019-07-25
申请号：US16373193
申请日：2019-04-02
Applicant: AJINOMOTO CO., INC.
Inventor： Hidehiro NAKAMURA , Natsumi NISHIKATA , Akira IMAIZUMI , Kazutaka SHIMBO , Naoko ARASHIDA , Rumi NISHIMOTO
IPC: G01N33/574 , G01N33/49 , G01N33/487
Abstract: An evaluating method includes an evaluating step of evaluating a state of pancreatic cancer for a subject to be evaluated using (i) a concentration value of at least one metabolite of N-Me-bABA, bABA, GABA, N6-Acetyl-L-Lys, 1-Me-His, aABA, Aminoadipic acid, bAiBA, Cadaverine, Ethylglycine, Homoarginine, Hypotaurine, Kinurenine, Putrescine, Serotonin, Spermidine, Spermine, ADMA, Homocitrulline, 3-Me-His, Hydroxyproline, Phosphoethanolamine, Acylcarnitine (13:1), and EPA in blood of the subject or (ii) a value of a formula calculated using the concentration value of the metabolite and the formula including an explanatory variable to be substituted with the concentration value of the metabolite.
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