公开(公告)号：US20180016580A1

公开(公告)日：2018-01-18

申请号：US15704467

申请日：2017-09-14

Applicant: AJINOMOTO CO., INC.

Inventor： Takayoshi TORII ,  Daisuke Takahashi ,  Satoshi Katayama

IPC: C12N15/113 ,  C07D519/00 ,  C12N15/11 ,  C07D413/04 ,  C07D487/04 ,  C07H21/00

CPC classification number: C12N15/113 ,  C07D413/04 ,  C07D487/04 ,  C07D519/00 ,  C07H21/00 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2330/30 ,  Y02P20/55

Abstract: Using a morpholino nucleotide wherein 5′-hydroxy group or a hydroxy group present on the substituent of the 5′-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided.

公开(公告)号：US20200040331A1

公开(公告)日：2020-02-06

申请号：US16582392

申请日：2019-09-25

Applicant: AJINOMOTO CO., INC.

Inventor： Daisuke TAKAHASHI ,  Takayoshi TORII

IPC: C12N15/11 ,  C07F9/6558 ,  C07F9/6533 ,  C12N15/09 ,  C12N15/113

Abstract: Morpholino oligonucleotides can be produced efficiently in a high yield by a liquid-phase synthesis method, which includes subjecting a reaction mixture of a condensation reaction to an extraction operation and separating the morpholino oligonucleotide as a resultant product to the organic layer side.