公开(公告)号：US09561216B2

公开(公告)日：2017-02-07

申请号：US14972362

申请日：2015-12-17

Applicant: AJINOMOTO CO., INC.

Inventor： Masayuki Sugiki ,  Toru Okamatsu ,  Tetsuo Yano ,  Shinya Taniguchi

IPC: A61K31/4402 ,  A23L27/20 ,  C07C275/42 ,  C07C309/51 ,  C07C311/32 ,  C07C311/51 ,  C07C333/08 ,  C07C335/16 ,  C07D209/14 ,  C07D213/74 ,  C07D233/61 ,  C07D271/10 ,  C07D295/16 ,  C07D413/04 ,  C07D213/75 ,  C07D295/192 ,  A61K31/185 ,  A61K31/198 ,  A61K31/27 ,  A61K31/4045 ,  A61K31/417 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/5375

CPC classification number: A61K31/4402 ,  A23L27/202 ,  A23L27/204 ,  A61K31/185 ,  A61K31/198 ,  A61K31/27 ,  A61K31/4045 ,  A61K31/417 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/5375 ,  C07C275/42 ,  C07C309/51 ,  C07C311/32 ,  C07C311/51 ,  C07C333/08 ,  C07C335/16 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/14 ,  C07D213/74 ,  C07D213/75 ,  C07D233/61 ,  C07D271/10 ,  C07D295/16 ,  C07D295/192 ,  C07D413/04

Abstract: A composition containing a compound represented by General Formula (I) below (see the definition in the specification for the symbols in the formula) or a salt thereof has an excellent CaSR agonistic effect and provides a pharmaceutical agent, a CaSR agonistic agent, a prophylactic or therapeutic agent for a disease that can be ameliorated through CaSR activation as well as seasonings and an agent for imparting kokumi.

Abstract translation: 含有下述通式（I）表示的化合物的组合物（参照式中的符号的说明书中的定义）或其盐具有优异的CaSR激动作用，并且提供药剂，CaSR激动剂，预防 或用于通过CaSR活化可以改善的疾病以及调味料和用于赋予小丸的药剂的治疗剂。

公开(公告)号：US20140303122A1

公开(公告)日：2014-10-09

申请号：US14229152

申请日：2014-03-28

Applicant: AJINOMOTO CO., INC.

Inventor： Masayuki SUGIKI ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

IPC: C07C237/04 ,  A23L1/226 ,  C07F9/38 ,  C07C309/51 ,  C07F9/40

CPC classification number: C07C237/04 ,  A23L27/204 ,  A23L27/22 ,  A23L33/175 ,  C07C309/51 ,  C07F9/3834 ,  C07F9/4018 ,  C07F9/4021

Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

Abstract translation: 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。

公开(公告)号：US09174932B2

公开(公告)日：2015-11-03

申请号：US14229152

申请日：2014-03-28

Applicant: AJINOMOTO CO., INC.

Inventor： Masayuki Sugiki ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

IPC: C07C237/04 ,  C07C309/51 ,  C07F9/38 ,  A23L1/228 ,  A23L1/305 ,  C07F9/40 ,  A23L1/226

CPC classification number: C07C237/04 ,  A23L27/204 ,  A23L27/22 ,  A23L33/175 ,  C07C309/51 ,  C07F9/3834 ,  C07F9/4018 ,  C07F9/4021

Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

Abstract translation: 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。