公开(公告)号：US20130102570A1

公开(公告)日：2013-04-25

申请号：US13630562

申请日：2012-09-28

Applicant: AJINOMOTO CO., INC

Inventor： Reiko YASUDA ,  Yuzuru Eto

IPC: A61K31/198 ,  A61K31/662 ,  A61K31/216 ,  A61K31/27

CPC classification number: A61K31/198 ,  A61K31/216 ,  A61K31/223 ,  A61K31/27 ,  A61K31/662 ,  C07F9/3834 ,  C07F9/4021

Abstract: A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

Abstract translation: 具有优异的CaSR激动剂作用的药物，其能够预防或治疗糖尿病或肥胖症由包含如所定义的通式（I）表示的化合物或其盐组成。

公开(公告)号：US09174932B2

公开(公告)日：2015-11-03

申请号：US14229152

申请日：2014-03-28

Applicant: AJINOMOTO CO., INC.

Inventor： Masayuki Sugiki ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

IPC: C07C237/04 ,  C07C309/51 ,  C07F9/38 ,  A23L1/228 ,  A23L1/305 ,  C07F9/40 ,  A23L1/226

CPC classification number: C07C237/04 ,  A23L27/204 ,  A23L27/22 ,  A23L33/175 ,  C07C309/51 ,  C07F9/3834 ,  C07F9/4018 ,  C07F9/4021

Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

Abstract translation: 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。

公开(公告)号：US08877739B2

公开(公告)日：2014-11-04

申请号：US13630562

申请日：2012-09-28

Applicant: Ajinomoto Co., Inc.

Inventor： Reiko Yasuda ,  Yuzuru Eto

IPC: A61K31/662

CPC classification number: A61K31/198 ,  A61K31/216 ,  A61K31/223 ,  A61K31/27 ,  A61K31/662 ,  C07F9/3834 ,  C07F9/4021

Abstract: A medicament having an excellent CaSR agonist action which enables the prevention or treatment of diabetes or obesity is provided by a composition comprising the compound represented by general formula (I) as defined, or a salt thereof.

Abstract translation: 具有优异的CaSR激动剂作用的药物，其能够预防或治疗糖尿病或肥胖症由包含如所定义的通式（I）表示的化合物或其盐的组合物提供。

公开(公告)号：US20140030380A1

公开(公告)日：2014-01-30

申请号：US14043195

申请日：2013-10-01

Applicant: AJINOMOTO CO., INC.

Inventor： Seiji Kitajima ,  Yuzuru Eto ,  Takaho Tajima

IPC: A23L1/22

CPC classification number: A23L27/21 ,  A23J3/16 ,  A23J3/346 ,  A23L27/26 ,  A23L27/88 ,  A23V2002/00 ,  C12P21/06 ,  A23V2200/16 ,  A23V2250/5488 ,  A23V2250/55

Abstract: The present invention provides a production method of a food, which can effectively enhance a taste without conferring an unpreferable or undesirable flavor, and a method for enhancing a taste of food. The present invention provides a method of producing a food with an enhanced taste, including by adding a peptide mixture obtained by hydrolyzing, with an enzyme, a composition containing β-conglycinin, and a method of enhancing the taste of food, including a step of adding the peptide mixture.

Abstract translation: 本发明提供一种食品的制造方法，其能够有效地增加味道而不赋予不优选或不期望的风味，以及增加食品味道的方法。 本发明提供一种生产具有增强味道的食品的方法，包括通过加入通过用酶水解含有β-伴大豆球蛋白的组合物获得的肽混合物和增强食物味道的方法，包括步骤 加入肽混合物。

公开(公告)号：US20130196050A1

公开(公告)日：2013-08-01

申请号：US13852434

申请日：2013-03-28

Applicant: AJINOMOTO CO., INC.

Inventor： Yusuke AMINO ,  Takami Maekawa ,  Yuzuru Eto ,  Megumi Kaneko ,  Yuki Tahara ,  Takashi Miyaki ,  Wakana Saikawa ,  Yuko Kai ,  Yutaka Ishiwatari

IPC: A23L1/221 ,  C07D209/22

CPC classification number: C07D209/14 ,  A23L27/204 ,  A23L27/2054 ,  A23L27/88 ,  C07C233/51 ,  C07C235/38 ,  C07C235/60 ,  C07C237/20 ,  C07C309/51 ,  C07D209/16 ,  C07D209/18 ,  C07D209/20 ,  C07D317/48 ,  C07D317/60 ,  C07D487/04

Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the specification, exhibit a salty taste enhancing activity and are useful as salty taste enhancers for foods and drinks.

Abstract translation: 由式（I）表示的化合物：其中每个符号如说明书中所定义，表现出咸味增强活性，并且可用作食品和饮料的咸味增强剂。

公开(公告)号：US20140303122A1

公开(公告)日：2014-10-09

申请号：US14229152

申请日：2014-03-28

Applicant: AJINOMOTO CO., INC.

Inventor： Masayuki SUGIKI ,  Toru Okamatsu ,  Sayaka Asari ,  Yayoi Kawato ,  Toshihiro Hatanaka ,  Tetsuo Yano ,  Yukie Seki ,  Naohiro Miyamura ,  Hiroaki Nagasaki ,  Yuzuru Eto ,  Reiko Yasuda

IPC: C07C237/04 ,  A23L1/226 ,  C07F9/38 ,  C07C309/51 ,  C07F9/40

CPC classification number: C07C237/04 ,  A23L27/204 ,  A23L27/22 ,  A23L33/175 ,  C07C309/51 ,  C07F9/3834 ,  C07F9/4018 ,  C07F9/4021

Abstract: By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

Abstract translation: 通过搜索具有CaSR激动活性的各种化合物，本发明提供了各自包含该化合物的CaSR激动剂，药物组合物，用于腹泻和赋形剂的预防或治疗剂。 更具体地，本发明提供了CaSR激动剂，药物组合物，用于腹泻和赋予Kokumi的预防或治疗剂，其各自包含具有CaSR激动活性的谷氨酸衍生物或其药学上可接受的盐。

公开(公告)号：US20140004243A1

公开(公告)日：2014-01-02

申请号：US14019993

申请日：2013-09-06

Applicant: AJINOMOTO CO., INC.

Inventor： Yuki TAHARA ,  Yusuke Amino ,  Takami Maekawa ,  Yuzuru Eto ,  Takashi Miyaki ,  Wakana Saikawa ,  Yuko Kai ,  Yutaka Ishiwatari

IPC: A23L1/237

CPC classification number: A23L27/88 ,  A23L27/40 ,  C07C335/12 ,  C07D209/14 ,  C07D209/16 ,  C07D209/44 ,  C07D213/40 ,  C07D217/06 ,  C07D233/86 ,  C07D235/14 ,  C07D307/52 ,  C07D317/58

Abstract: The present invention provides a compound having a salty taste enhance activity, and a salty taste enhancer containing the compound, and the like.The present invention relates to a salty taste enhancer for a food or drink, which contains a compound represented by the following formula: wherein each symbol is as defined in the specification, or an edible salt thereof.

Abstract translation: 本发明提供具有咸味增强活性的化合物和含有该化合物的咸味增强剂等。 本发明涉及食品或饮料的咸味增强剂，其含有下式表示的化合物：其中各符号如说明书中所定义，或其食用盐。