公开(公告)号：US20240366783A1

公开(公告)日：2024-11-07

申请号：US18666145

申请日：2024-05-16

Applicant: AJINOMOTO CO., INC.

Inventor： Kei YAMADA ,  Yutaka MATSUDA ,  Tomohiro FUJII ,  Natsuki SHIKIDA ,  Reiko YUJI ,  Kazutaka SHIMBO ,  Yuji ITO

IPC: A61K47/68 ,  C07K16/00 ,  C07K19/00

Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R  (I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.