公开(公告)号：US20160041189A1

公开(公告)日：2016-02-11

申请号：US14766759

申请日：2013-08-30

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Byung Gon KIM ,  Jun Young CHOI

IPC: G01N33/68 ,  A61K38/08 ,  C12Q1/68

CPC classification number: G01N33/6896 ,  A61K31/716 ,  A61K31/739 ,  A61K38/08 ,  A61K38/14 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2800/2871

Abstract: The present invention relates to a biomarker composition for detecting white matter stroke, the biomarker composition containing a toll-like receptor 2 (TLR2), and a medical use using the TLR2. The TLR2 can be used as a biomarker for white matter stroke by defending against ischemic demyelination and oligodendrocyte death, and when targeting the TLR2, ischemic white matter stroke can be treated or prevented.

Abstract translation: 本发明涉及一种用于检测白质中风的生物标志物组合物，含有toll样受体2（TLR2）的生物标志物组合物和使用该TLR2的医学用途。 TLR2可用作白细胞中风的生物标志物，用于防止缺血性脱髓鞘和少突胶质细胞死亡，当靶向TLR2时，可以治疗或预防缺血性白质中风。

公开(公告)号：US20240264149A1

公开(公告)日：2024-08-08

申请号：US18472987

申请日：2023-09-22

Applicant: Ajou University Industry-Academic Cooperation Foundation

Inventor： Byung Gon KIM ,  Hyung Soon KIM

IPC: G01N33/50 ,  A61K45/06 ,  A61P25/28 ,  C12N15/113 ,  G01N33/68

CPC classification number: G01N33/5023 ,  A61K45/06 ,  A61P25/28 ,  C12N15/1137 ,  G01N33/5058 ,  G01N33/6863

Abstract: The present disclosure relates to a composition for preventing or treating ischemic cerebrovascular disease, and more specifically to a composition for preventing or treating ischemic cerebrovascular disease including an arginase-1 inhibitor as an active ingredient, and the arginase-1 inhibitor according to the present disclosure can alleviate pathological damage caused by the interaction of inflammatory cells after ischemic stroke and promote functional recovery by inhibiting the expression and function of cell-specific arginase-1 protein.