公开(公告)号：US20140377322A1

公开(公告)日：2014-12-25

申请号：US14309911

申请日：2014-06-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong PARK ,  Jong Hoon CHOI

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/727 ,  A61K45/06 ,  A61K31/137 ,  A61K31/337

CPC classification number: A61K45/06 ,  A61K31/137 ,  A61K31/337 ,  A61K31/727 ,  A61K47/48215 ,  A61K47/60 ,  A61L27/52 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2420/08

Abstract: Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

Abstract translation: 本发明公开了一种用于药物储存器的多层结构，包括用于交联和粘附的第一胶束层，其包含药物，多臂聚合物，苯酚衍生物和多巴衍生物并具有一层或两层结构; 层叠在第一胶束层上的用于交联的第二胶束层，包含药物，多臂聚合物和苯酚衍生物，并具有一层或两层结构; 和层叠在第二胶束层上的生理活性物质层，其包含生理活性物质，水溶性聚合物和苯酚衍生物，并且具有一层或两层结构。