公开(公告)号：US20170281781A1

公开(公告)日：2017-10-05

申请号：US15475948

申请日：2017-03-31

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong PARK ,  Kyung Min PARK ,  Yun Ki LEE ,  Thi Thai Thanh HOANG ,  Thi Phuong LE

IPC: A61K47/40 ,  A61K9/06 ,  A61L31/04 ,  A61K9/00

CPC classification number: A61K47/40 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61L26/0066 ,  A61L26/008 ,  A61L2400/06 ,  A61L2430/34

Abstract: Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (γ-CD). When such an injectable tissue adhesive hydrogel including the γ-CD is used as a skin glue, based on a fact that the γ-CD has a bigger hydrophobic cavity than that of α- and β-CDs, the injectable tissue adhesive hydrogel including the γ-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the γ-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the γ-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.

公开(公告)号：US20250161537A1

公开(公告)日：2025-05-22

申请号：US18836391

申请日：2022-11-04

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  SEOUL NATIONAL UNIVERSITY HOSPITAL

Inventor： Ki Dong PARK ,  Si Min LEE ,  Se Joon WOO ,  Hye Kyoung HONG

IPC: A61L27/52 ,  A61L27/02 ,  A61L27/14 ,  A61L27/54

Abstract: The present invention relates to an injectable hydrogel rod using a crosslinked hydrogel, a method for manufacturing same, and biomedical use thereof. According to the present invention, by adjusting the contents of a polymer, an enzyme and hydrogen peroxide to a certain ratio to manufacture an injectable hydrogel rod, the initial release amount of a drug injected into the hydrogel rod is controlled, and thus, compared to existing hydrogel-based injectable implants, the hydrogel rod exhibits sustained release above an effective concentration for a long period of time and greatly reduces elimination into surrounding tissues, which may result in an increased therapeutic effect and remarkably reduced side effects.

公开(公告)号：US20210154373A1

公开(公告)日：2021-05-27

申请号：US16952627

申请日：2020-11-19

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong PARK ,  Le Thi PHUONG ,  Tran Dieu LINH

IPC: A61L31/16 ,  A61L31/14 ,  A61L31/02

Abstract: The present disclosure relates to a method for immobilizing heparin and a NO-generating catalyst and a cardiovascular device having a surface modified using the same, and more particularly, to a method of co-immobilizing a heparin-phenol derivative and copper nanoparticles as a NO-generating catalyst on the surface of a material by a polyphenol oxidase-mediated reaction, a material having a surface with heparin and a NO-generating catalyst co-immobilized thereon by using the method, and a cardiovascular device including the material. It has been confirmed that a surface having heparin and the NO-generating catalyst co-immobilized thereon by the method of the present disclosure has high in vivo stability, continuously generates NO, and also promotes the proliferation of endothelial cells while significantly inhibiting the adhesion and activation of platelets and smooth muscle cells. Thus, the method may be advantageously applied to cardiovascular devices for inhibiting thrombosis and restenosis.

公开(公告)号：US20180369538A1

公开(公告)日：2018-12-27

申请号：US15780834

申请日：2016-11-04

Applicant: THE ASAN FOUNDATION ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Deok Hee LEE ,  Ji Hoon SHIN ,  Seon Moon HWANG ,  Tae Il KIM ,  Ga Young LEE ,  Eun Joung KIM ,  Jin Ho YOON ,  Seng Yong CHUN ,  Ki Dong PARK ,  Yun Ki LEE

IPC: A61M25/00 ,  A61L29/14

Abstract: Provided is a catheter to be inserted into an object. The catheter includes a main body having a tubular shape and an expansion layer formed on an outer circumferential surface of the main body, and the expansion layer contains an expandable material which is expanded by contact with a liquid.

公开(公告)号：US20140377322A1

公开(公告)日：2014-12-25

申请号：US14309911

申请日：2014-06-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Dong PARK ,  Jong Hoon CHOI

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/727 ,  A61K45/06 ,  A61K31/137 ,  A61K31/337

CPC classification number: A61K45/06 ,  A61K31/137 ,  A61K31/337 ,  A61K31/727 ,  A61K47/48215 ,  A61K47/60 ,  A61L27/52 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2420/08

Abstract: Disclosed is a multi-layered structure for drug reservoir, comprising a first micelle layer for crosslinking and adhesion, comprising a drug, a multi-arm polymer, a phenol derivative, and a dopa derivative and having a one or two-layered structure; a second micelle layer for crosslinking, being stacked on the first micelle layer, comprising a drug, a multi-arm polymer, and a phenol derivative, and having a one or two-layered structure; and a physiologically active material layer, being stacked on the second micelle layer, comprising a physiologically active material, a water-soluble polymer, and a phenol derivative, and having a one or two-layered structure.

Abstract translation: 本发明公开了一种用于药物储存器的多层结构，包括用于交联和粘附的第一胶束层，其包含药物，多臂聚合物，苯酚衍生物和多巴衍生物并具有一层或两层结构; 层叠在第一胶束层上的用于交联的第二胶束层，包含药物，多臂聚合物和苯酚衍生物，并具有一层或两层结构; 和层叠在第二胶束层上的生理活性物质层，其包含生理活性物质，水溶性聚合物和苯酚衍生物，并且具有一层或两层结构。