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公开(公告)号：US20150057593A1
公开(公告)日：2015-02-26
申请号：US13975316
申请日：2013-08-24
申请人： ALCON RESEARCH, LTD.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2240/001 , A61F2250/0003 , Y10T29/49826
摘要： An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein.
摘要翻译： 提供了用于植入患者眼睛的眼内装置。 眼内装置包括入口管，出口管和微流体室。 微流体室包括耦合到入口管的室入口，联接到出口管的室出口和一个或多个流体阻挡层。 每个流体屏障构造成使得当任何流体超过流体屏障之前，当流体被注入到微流体室中时，流体的前部与流体屏障重合。 本文还公开了相关方法。
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公开(公告)号：US20150057595A1
公开(公告)日：2015-02-26
申请号：US13975322
申请日：2013-08-24
申请人： ALCON RESEARCH, LTD.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61B3/16 , A61F2250/0002
摘要： Described herein is an IOP control device for implantation in an eye of a patient, comprising a drainage tube, a pressure-driven flow system, and a flow rate measurement system. The drainage tube includes a drainage lumen in fluid communication with an anterior chamber of the eye. The flow system is in fluid communication with the drainage lumen, and is configured to control the flow of fluid through the drainage tube. The flow rate measurement system is disposed distal to the flow system, and comprises a flow tube including a known hydraulic resistance to flow, a proximal pressure sensor disposed at the proximal end of the flow tube, and a distal pressure sensor disposed at the distal end of the flow tube. The flow tube includes a proximal end, a distal end, and a lumen extending therebetween that is configured to be in fluid communication with the drainage lumen.
摘要翻译： 本文描述了用于植入患者眼睛的IOP控制装置，包括排液管，压力驱动流系统和流量测量系统。 引流管包括与眼睛前房流体连通的排液腔。 流动系统与排水腔流体连通，并且被配置成控制通过排水管的流体的流动。 流量测量系统设置在流动系统的远侧，并且包括流动管，其包括已知的液压阻力流，设置在流管近端的近侧压力传感器和设置在远端的远侧压力传感器 的流管。 流管包括近端，远端和在其间延伸的内腔，其构造成与排液腔流体连通。
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公开(公告)号：US20150057583A1
公开(公告)日：2015-02-26
申请号：US13975312
申请日：2013-08-24
申请人： ALCON RESEARCH, LTD.
CPC分类号： A61H5/00 , A61H23/004 , A61H23/02 , A61H2201/5038
摘要： An implantable device for mechanically stimulating the trabecular meshwork is disclosed. The device is implanted in the eye adjacent the trabecular meshwork. The device imparts mechanical stimulating in the form of vibrations or movement to the trabecular meshwork. The imparted mechanical stimulation causes the trabecular meshwork to move in a manner that produces a pumping action to remove aqueous from the anterior chamber of the eye.
摘要翻译： 公开了一种用于机械刺激小梁网的可植入装置。 该装置植入邻近小梁网的眼睛。 该装置将振动或运动的形式的机械刺激施加到小梁网。 所施加的机械刺激使得小梁网以产生泵送作用以从眼睛的前房去除水分的方式移动。
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公开(公告)号：US09289324B2
公开(公告)日：2016-03-22
申请号：US13975870
申请日：2013-08-26
申请人： ALCON RESEARCH, LTD.
CPC分类号： A61F9/00781 , A61F2250/0002
摘要： Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway.
摘要翻译： 本文描述了一种用于植入患者眼睛的IOP控制装置，包括一个包括入口和出口的壳体，流体流动通道构造成允许流体从入口流到出口，并且在 锚固在壳体内的至少一个阀。 所述至少一个阀包括第一侧和相对的第二侧，并且被配置为响应于作用在相对的第一和第二侧上的压差而通过移动而影响通过流体流动通道从入口端口到出口端口的流动。 所述至少一个阀可以在增加对流体流动通道内的流体流动的阻力增加的活动状态和降低对流体流动通道内的流体流动的阻力的非活动状态之间进行远程调节。
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公开(公告)号：US09283114B2
公开(公告)日：2016-03-15
申请号：US13975316
申请日：2013-08-24
申请人： ALCON RESEARCH, LTD.
CPC分类号： A61F9/00781 , A61F2240/001 , A61F2250/0003 , Y10T29/49826
摘要： An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein.
摘要翻译： 提供了用于植入患者眼睛的眼内装置。 眼内装置包括入口管，出口管和微流体室。 微流体室包括耦合到入口管的室入口，联接到出口管的室出口和一个或多个流体阻挡层。 每个流体屏障构造成使得当任何流体超过流体屏障之前，当流体被注入到微流体室中时，流体的前部与流体屏障重合。 本文还公开了相关方法。
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公开(公告)号：US20150057597A1
公开(公告)日：2015-02-26
申请号：US13975870
申请日：2013-08-26
申请人： ALCON RESEARCH, LTD.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F2250/0002
摘要： Described herein is an IOP control device for implantation in an eye of a patient, comprising a housing including an inlet port and an outlet port, a fluid flow passageway configured to allow the flow of fluid from the inlet port to the outlet port, and at least one valve anchored within the housing. The at least one valve includes a first side and an opposing second side, and is configured to affect flow through the fluid flow passageway from the inlet port to the outlet port by moving in response to pressure differentials acting on the opposing first and second sides. The at least one valve is remotely adjustable between an active condition increasing resistance to the flow of fluid within the fluid flow passageway and an inactive condition decreasing resistance to the flow of fluid within the fluid flow passageway.
摘要翻译： 本文描述了一种用于植入患者眼睛的IOP控制装置，包括一个包括入口和出口的壳体，流体流动通道构造成允许流体从入口流到出口，并且在 锚固在壳体内的至少一个阀。 所述至少一个阀包括第一侧和相对的第二侧，并且被配置为响应于作用在相对的第一和第二侧上的压差而通过移动而影响通过流体流动通道从入口端口到出口端口的流动。 所述至少一个阀可以在增加对流体流动通道内的流体流动的阻力增加的活动状态和降低对流体流动通道内的流体流动的阻力的非活动状态之间进行远程调节。
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公开(公告)号：US20150057594A1
公开(公告)日：2015-02-26
申请号：US13975320
申请日：2013-08-24
申请人： ALCON RESEARCH, LTD.
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2250/0003 , A61M2205/0244 , A61M2210/0612 , B81B2201/054 , B81B2203/0127 , F16K99/0015 , F16K99/0057 , F16K2099/0088 , Y10T137/7895
摘要： A microfluidic valve for implantation in an eye of a patient is disclosed. The valve may include a chamber formed between a substrate and a flexible membrane. The valve may also include a boss disposed in the chamber and having a top edge in selective contact with the flexible membrane. The top edge includes a relief portion and a non-relief portion, with the relief portion being structurally arranged so that a pressure required to separate the membrane from the relief portion is less than a pressure required to separate the membrane from the non-relief portion. The valve also may include an inlet extending through the boss and the substrate through which fluid enters the chamber and an outlet configured to allow fluid to exit the chamber. Methods for priming a microfluidic valve are also disclosed.
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