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    PRESSURE-BASED FLOW RATE MEASUREMENT FOR OCULAR IMPLANTS
    1.
    发明申请
    PRESSURE-BASED FLOW RATE MEASUREMENT FOR OCULAR IMPLANTS 审中-公开
    基于压力的流动速率测量用于OCURAR IMPLANTS

    公开(公告)号：US20150057595A1

    公开(公告)日：2015-02-26

    申请号：US13975322

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Nicholas Max Gunn ,  Andrew David Johnson

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61F2250/0002

    摘要： Described herein is an IOP control device for implantation in an eye of a patient, comprising a drainage tube, a pressure-driven flow system, and a flow rate measurement system. The drainage tube includes a drainage lumen in fluid communication with an anterior chamber of the eye. The flow system is in fluid communication with the drainage lumen, and is configured to control the flow of fluid through the drainage tube. The flow rate measurement system is disposed distal to the flow system, and comprises a flow tube including a known hydraulic resistance to flow, a proximal pressure sensor disposed at the proximal end of the flow tube, and a distal pressure sensor disposed at the distal end of the flow tube. The flow tube includes a proximal end, a distal end, and a lumen extending therebetween that is configured to be in fluid communication with the drainage lumen.

    摘要翻译： 本文描述了用于植入患者眼睛的IOP控制装置，包括排液管，压力驱动流系统和流量测量系统。 引流管包括与眼睛前房流体连通的排液腔。 流动系统与排水腔流体连通，并且被配置成控制通过排水管的流体的流动。 流量测量系统设置在流动系统的远侧，并且包括流动管，其包括已知的液压阻力流，设置在流管近端的近侧压力传感器和设置在远端的远侧压力传感器 的流管。 流管包括近端，远端和在其间延伸的内腔，其构造成与排液腔流体连通。

    TRABECULAR MESHWORK STIMULATION DEVICE
    2.
    发明申请
    TRABECULAR MESHWORK STIMULATION DEVICE 审中-公开
    TRABECULAR MESHWORK刺激装置

    公开(公告)号：US20150057583A1

    公开(公告)日：2015-02-26

    申请号：US13975312

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Nicholas Max Gunn ,  Andrew David Johnson ,  Casey Jean Lind ,  Robert Joseph Sanchez, JR.

    IPC分类号： A61H5/00 ,  A61H23/02

    CPC分类号： A61H5/00 ,  A61H23/004 ,  A61H23/02 ,  A61H2201/5038

    摘要： An implantable device for mechanically stimulating the trabecular meshwork is disclosed. The device is implanted in the eye adjacent the trabecular meshwork. The device imparts mechanical stimulating in the form of vibrations or movement to the trabecular meshwork. The imparted mechanical stimulation causes the trabecular meshwork to move in a manner that produces a pumping action to remove aqueous from the anterior chamber of the eye.

    摘要翻译： 公开了一种用于机械刺激小梁网的可植入装置。 该装置植入邻近小梁网的眼睛。 该装置将振动或运动的形式的机械刺激施加到小梁网。 所施加的机械刺激使得小梁网以产生泵送作用以从眼睛的前房去除水分的方式移动。

    SYSTEMS AND METHODS FOR PRIMING A MICROFLUIDIC CHAMBER
    3.
    发明申请
    SYSTEMS AND METHODS FOR PRIMING A MICROFLUIDIC CHAMBER 有权
    用于引导微流化室的系统和方法

    公开(公告)号：US20150057593A1

    公开(公告)日：2015-02-26

    申请号：US13975316

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Andrew David Johnson ,  Nicholas Max Gunn

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00781 ,  A61F2240/001 ,  A61F2250/0003 ,  Y10T29/49826

    摘要： An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein.

    摘要翻译： 提供了用于植入患者眼睛的眼内装置。 眼内装置包括入口管，出口管和微流体室。 微流体室包括耦合到入口管的室入口，联接到出口管的室出口和一个或多个流体阻挡层。 每个流体屏障构造成使得当任何流体超过流体屏障之前，当流体被注入到微流体室中时，流体的前部与流体屏障重合。 本文还公开了相关方法。

    Systems and methods for priming a microfluidic chamber
    4.
    发明授权
    Systems and methods for priming a microfluidic chamber 有权
    用于引发微流体室的系统和方法

    公开(公告)号：US09283114B2

    公开(公告)日：2016-03-15

    申请号：US13975316

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Andrew David Johnson ,  Nicholas Max Gunn

    IPC分类号： A61M5/00 ,  A61F9/007

    CPC分类号： A61F9/00781 ,  A61F2240/001 ,  A61F2250/0003 ,  Y10T29/49826

    摘要： An intraocular device for implantation in an eye of a patient is provided. The intraocular device includes an inlet tube, an outlet tube, and a microfluidic chamber. The microfluidic chamber includes a chamber inlet coupled to the inlet tube, a chamber outlet coupled to the outlet tube, and one or more fluidic barriers. Each fluidic barrier is configured such that, as a fluid is injected into the microfluidic chamber, a front of the fluid coincides with the fluidic barrier before any of the fluid passes beyond the fluidic barrier. Associated methods are also disclosed herein.

    摘要翻译： 提供了用于植入患者眼睛的眼内装置。 眼内装置包括入口管，出口管和微流体室。 微流体室包括耦合到入口管的室入口，联接到出口管的室出口和一个或多个流体阻挡层。 每个流体屏障构造成使得当任何流体超过流体屏障之前，当流体被注入到微流体室中时，流体的前部与流体屏障重合。 本文还公开了相关方法。

    MEMS CHECK VALVE CHIP AND METHODS
    5.
    发明申请
    MEMS CHECK VALVE CHIP AND METHODS 有权
    MEMS检查阀芯和方法

    公开(公告)号：US20150057592A1

    公开(公告)日：2015-02-26

    申请号：US13975307

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Nicholas Max Gunn

    IPC分类号： A61F9/007

    CPC分类号： A61F9/00781 ,  A61B3/16

    摘要： A MEMS check valve chip is described. The chip comprises a first side and an opposing second side, an outlet port extending from the first side to the second side, and a flexible outlet membrane anchored to the first side to overlie the outlet port. The flexible outlet membrane includes an outlet aperture and a sealing portion, and the sealing portion is movable between a closed position inhibiting fluid flow through the outlet aperture and an open position wherein the sealing portion displaces into the outlet port to permit fluid flow through the outlet aperture.

    摘要翻译： 描述了一种MEMS止回阀芯片。 芯片包括第一侧和相对的第二侧，从第一侧延伸到第二侧的出口端口以及锚固到第一侧以覆盖出口的柔性出口膜。 柔性出口膜包括出口孔和密封部分，并且密封部分可在禁止流过出口孔的流体的关闭位置和打开位置之间移动，其中密封部分移动到出口端口中，以允许流体流过出口 光圈。

    MEMS check valve chip and methods
    6.
    发明授权
    MEMS check valve chip and methods 有权
    MEMS止回阀芯片及方法

    公开(公告)号：US09226851B2

    公开(公告)日：2016-01-05

    申请号：US13975307

    申请日：2013-08-24

    申请人： ALCON RESEARCH, LTD.

    发明人： Nicholas Max Gunn

    IPC分类号： A61M5/00 ,  A61F9/007 ,  A61B3/16

    CPC分类号： A61F9/00781 ,  A61B3/16

    摘要： A MEMS check valve chip is described. The chip comprises a first side and an opposing second side, an outlet port extending from the first side to the second side, and a flexible outlet membrane anchored to the first side to overlie the outlet port. The flexible outlet membrane includes an outlet aperture and a sealing portion, and the sealing portion is movable between a closed position inhibiting fluid flow through the outlet aperture and an open position wherein the sealing portion displaces into the outlet port to permit fluid flow through the outlet aperture.

    摘要翻译： 描述了一种MEMS止回阀芯片。 芯片包括第一侧和相对的第二侧，从第一侧延伸到第二侧的出口端口以及锚固到第一侧以覆盖出口的柔性出口膜。 柔性出口膜包括出口孔和密封部分，并且密封部分可在禁止流过出口孔的流体的关闭位置和打开位置之间移动，其中密封部分移动到出口端口中，以允许流体流过出口 光圈。

    SYSTEMS AND METHODS FOR PRIMING AN INTRAOCULAR PRESSURE SENSOR CHAMBER
    8.
    发明申请
    SYSTEMS AND METHODS FOR PRIMING AN INTRAOCULAR PRESSURE SENSOR CHAMBER 审中-公开
    用于引导室内压力传感器室的系统和方法

    公开(公告)号：US20150057523A1

    公开(公告)日：2015-02-26

    申请号：US13972608

    申请日：2013-08-21

    申请人： Alcon Research, Ltd.

    发明人： Nicholas Max Gunn

    IPC分类号： A61B3/16 ,  H01R43/00

    CPC分类号： A61B3/16 ,  A61B5/6867 ,  A61F9/00781 ,  Y10T29/49169

    摘要： An intraocular pressure monitoring and sensing device for implantation in an eye of a patient may include a substrate having a pressure sensor disposed on a top surface thereof and a pressure sensor cap disposed on the substrate over the pressure sensor. The pressure sensor cap may include a wall structure extending from the top surface of the substrate, the wall structure laterally surrounding the pressure sensor. The pressure sensor cap may further include a cap top situated above the pressure sensor, the cap top and wall structure together forming an interior chamber, and a chamber inlet providing fluid access to the interior chamber. At least one of the cap top and the wall structure includes a semi-permeable surface to aid in priming.

    摘要翻译： 用于植入患者眼睛的眼内压监测和感测装置可以包括具有设置在其顶表面上的压力传感器的基板和设置在压力传感器上的基板上的压力传感器盖。 压力传感器盖可以包括从基板的顶表面延伸的壁结构，壁结构横向围绕压力传感器。 压力传感器盖还可以包括位于压力传感器上方的帽顶部，帽顶部和壁部结构一起形成内部腔室，并且腔室入口提供流体进入内部腔室。 顶盖和墙壁结构中的至少一个包括半渗透表面以辅助起泡。

    Osmotically Actuated Fluidic Valve
    9.
    发明申请
    Osmotically Actuated Fluidic Valve 有权
    渗透式致动流体阀

    公开(公告)号：US20140172090A1

    公开(公告)日：2014-06-19

    申请号：US14090192

    申请日：2013-11-26

    申请人： Alcon Research, Ltd.

    发明人： Nicholas Max Gunn

    IPC分类号： A61F2/16

    CPC分类号： A61F9/00781 ,  A61N1/0428 ,  A61N1/0543

    摘要： An implantable fluidic valve actuated by osmotic pressure gradient and methods of operating it are provided. The valve includes: an input fluid channel; an output fluid channel in fluid communication with the input fluid channel at an aperture; and a semi-permeable membrane forming a portion of a sealed chamber. The semi-permeable membrane may have an outer surface forming a wall of the input fluid channel, and an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage. A pump including the above elements and a check valve is provided. An ocular implant including an inlet tube sized to receive aqueous humor and an intra-ocular pressure control system having a fluidic valve as above is also provided.

    摘要翻译： 提供了通过渗透压梯度驱动的可植入流体阀和操作它的方法。 该阀包括：输入流体通道; 在孔处与输入流体通道流体连通的输出流体通道; 以及形成密封室的一部分的半透膜。 半透膜可以具有形成输入流体通道的壁的外表面和形成密封室的壁的内表面，该膜被配置为允许溶剂扩散到密封室中并从密封室中流出; 以及设置在所述密封室内的第一电极和第二电极，所述第一电极和第二电极被配置为接收电压。 提供包括上述元件和止回阀的泵。 还提供了一种眼部植入物，其包括尺寸适于接收房水的入口管和具有如上所述的流体阀的眼内压力控制系统。