公开(公告)号：US20240350008A1

公开(公告)日：2024-10-24

申请号：US18685009

申请日：2022-08-22

申请人： NATIONAL UNIVERSITY OF SINGAPORE ,  NATIONAL UNIVERSITY HOSPITAL (SINGAPORE) PTE LTD

发明人： Chee Keong TEE ,  Kelu YU ,  Si LI ,  Victor KOH ,  Kwok Hung LEE

IPC分类号： A61B3/16

CPC分类号： A61B3/16

摘要： A system and method for measuring intraocular pressure (IOP) of the eye. The method 5 comprises the steps of touching the eyelid with a pressure sensor array; obtaining a spatiotemporal representation of pressure sensor stimulation of the pressure sensor array while touching the eyelid with the pressure sensor array; and applying a machine learning model to classify the spatiotemporal representation into an IOP value.

公开(公告)号：US12114931B2

公开(公告)日：2024-10-15

申请号：US17370735

申请日：2021-07-08

申请人： SmartLens, Inc.

发明人： Aykutlu Dana ,  Sevda Agaoglu ,  Ahmet Taylan Yazici ,  Murat Baday ,  Savas Komban

IPC分类号： A61B3/16 ,  A61M35/00 ,  G02B5/30 ,  G02C7/02 ,  H04N23/57

CPC分类号： A61B3/16 ,  A61M35/10 ,  G02B5/30 ,  G02C7/02 ,  H04N23/57

摘要： A wearable eyewear device, methods of use and systems are described that allow a person wearing the eyewear device to accurately measure the intraocular pressure of their eye, and dispense a medication to the eye when needed.

公开(公告)号：US12005178B2

公开(公告)日：2024-06-11

申请号：US17079218

申请日：2020-10-23

申请人： ELECTRONIC SYSTEMS S.P.A.

发明人： Roberto Citterio ,  Antonio Farago′ ,  Guido Santus

IPC分类号： A61M1/00 ,  A61B3/16 ,  A61B90/30 ,  A61F9/007 ,  A61M3/02 ,  A61B3/00 ,  A61B17/34 ,  A61B90/00

CPC分类号： A61M1/77 ,  A61B3/16 ,  A61B90/30 ,  A61F9/007 ,  A61F9/00781 ,  A61M1/777 ,  A61M1/85 ,  A61M3/0216 ,  A61B3/0008 ,  A61B17/34 ,  A61B2090/033 ,  A61B2090/036 ,  A61B2090/064 ,  A61M2205/3344 ,  A61M2205/587 ,  A61M2210/0612

摘要： A surgical assembly for ocular surgery includes a direct measuring device of intraocular pressure, a surgical accessory utilisable in conjunction with a surgical instrument suitable for performing eye surgery, and the surgical accessory being insertable in an ocular cavity through an accessory ocular incision. The direct measuring device of intraocular pressure is coupled to the surgical accessory so as to be insertable in the ocular cavity along with the surgical accessory through the accessory ocular incision.

公开(公告)号：US11998603B2

公开(公告)日：2024-06-04

申请号：US17953241

申请日：2022-09-26

申请人： Paragon BioTeck, Inc.

发明人： Patrick H. Witham ,  Sailaja Machiraju

IPC分类号： A61K47/10 ,  A61B3/16 ,  A61K9/00 ,  A61K9/08 ,  A61K31/245 ,  A61K47/02 ,  A61K47/32 ,  A61K49/00

CPC分类号： A61K47/10 ,  A61B3/16 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/245 ,  A61K47/02 ,  A61K47/32 ,  A61K49/0004 ,  A61K49/0043 ,  A61K49/006

摘要： Compositions comprising a fluorescein component and benoxinate component and the corresponding uses of these compositions are described herein. These compositions have improved storage life and the fluorescein component and/or benoxinate component minimally degrade after 12 to 18 months of storage.

公开(公告)号：US11947195B2

公开(公告)日：2024-04-02

申请号：US17051665

申请日：2018-11-20

申请人： Iowa State University Research Foundation, Inc.

发明人： Long Que ,  Gil Ben-Shlomo ,  Chao Song

IPC分类号： G02C7/04 ,  A61B3/16 ,  A61B5/00 ,  A61B5/145 ,  A61B90/00 ,  A61F9/00 ,  G02B1/04 ,  G02B1/10

CPC分类号： G02C7/049 ,  A61B3/16 ,  A61B5/14507 ,  A61B5/4839 ,  A61B5/6821 ,  A61B90/39 ,  A61F9/0008 ,  G02B1/043 ,  G02B1/10 ,  A61F2250/0024 ,  A61F2250/0097

摘要： Various embodiments disclosed relate to contact lens including nanopores. A contact lens can include a nanoporous film including nanopores that are on an inner surface of the contact lens, and a backing lens on the nanoporous film. Various embodiments further include a biomarker-sensing region of the nanoporous film, a drug storage and delivery region of the nanoporous film, or a combination thereof.

公开(公告)号：US20230414101A1

公开(公告)日：2023-12-28

申请号：US18243869

申请日：2023-09-08

申请人： Equinox Ophthalmic, Inc.

发明人： John Berdahl ,  George Tsai ,  Hal Walbrink ,  Vance Michael Thompson ,  Enrico Brambilla

IPC分类号： A61B3/16 ,  A61B5/00

CPC分类号： A61B3/16 ,  A61B5/4836

摘要： An apparatus to treat, inhibit, or prevent an eye condition in a patient can include a cover, sized and shaped to fit over an eye of a patient to define a cavity between the cover and an anterior surface of the eye when the cover is located over the patient eye. The apparatus can include a pressure source, in communication with the cavity, capable of applying non-ambient pressure in the cavity. The apparatus can include control circuitry, in communication with the pressure source, configured to vary non-ambient pressure applied to the cavity to affect a targeted pressure relationship between an indication of a first physiological pressure level and a second physiological pressure level associated with the eye of the patient.

公开(公告)号：US20230390110A1

公开(公告)日：2023-12-07

申请号：US18134988

申请日：2023-04-14

申请人： Injectsense, Inc.

发明人： Jose Padovani ,  Hakan Ates Gurcan ,  Ariel Cao ,  David Huber

IPC分类号： A61F9/00 ,  A61B3/16 ,  A61F9/007 ,  A61N1/36

CPC分类号： A61F9/0017 ,  A61N1/36046 ,  A61F9/00781 ,  A61B3/16

摘要： The disclosed apparatus, systems and methods relate to a smart minimally invasive glaucoma surgery (Smart-MIGS) device configured for passive and active flow. Various implementations are defined by a combination device that integrates intraocular pressure (IOP) monitoring, drug delivery and a drainage function for pressure control in the body or bodily region of a subject.

公开(公告)号：US20230380686A1

公开(公告)日：2023-11-30

申请号：US18447033

申请日：2023-08-09

申请人： Smartlens, Ins.

发明人： Ismail Emre Araci ,  Sevda Agaoglu ,  Murat Baday ,  Priscilla Diep

IPC分类号： A61B3/16 ,  G02C7/04

CPC分类号： A61B3/16 ,  G02C7/04 ,  A61B2562/0261

摘要： A microfluidic strain sensing device for monitoring intraocular pressure. The device has a contact lens and a closed microfluidic network embedded with the contact lens. The network has a volume that is sensitive to an applied strain. The network distinguishes: (i) a gas reservoir containing a gas, (ii) a liquid reservoir containing a liquid that changes volume when the strain is applied, and (iii) a sensing channel able to hold the liquid within the sensing channel. The sensing channel connects the gas reservoir on one end and connects the liquid reservoir on another end. The sensing channel establishes a liquid-gas equilibrium pressure interface and equilibrium within the sensing channel, which would fluidically change as a response to radius of curvature variations on a cornea, or as a response to mechanical stretching and release of the cornea. The liquid-gas equilibrium pressure interface and equilibrium are used for measuring the intraocular pressure.

公开(公告)号：US20230337983A1

公开(公告)日：2023-10-26

申请号：US17971060

申请日：2022-10-21

申请人： MINGCHE BIOTECHNOLOGY CO., LTD

发明人： Dongni REN ,  Fule WANG ,  Kemin WANG ,  Ruixue YIN ,  Heming WEI ,  Hongbo ZHANG

IPC分类号： A61B5/00 ,  A61B3/16

CPC分类号： A61B5/6847 ,  A61B3/16 ,  A61B2562/168

摘要： An intraocular pressure (IOP) includes a transmission film component, which is in direct contact with intraocular aqueous humor and configured to sense pressure fluctuations in the intraocular aqueous humor; a reflective film component set on an inner side of the transmission film component; and an adhesion layer component set on an inner layer of the reflective film component and configured to connect to an attachment device. An enclosed space formed by the reflective film component and the transmission film component constitutes a resonance chamber, which is filled with a filling medium. When a pressure in the intraocular aqueous humor is changed, the transmission film component is deformed, resulting in a change in a near-infrared (NIR) spectrum reflected by the reflective film component; the TOP is detected according to the change of the NIR spectrum.

公开(公告)号：US20230277376A1

公开(公告)日：2023-09-07

申请号：US18196259

申请日：2023-05-11

申请人： Twenty Twenty Therapeutics LLC

发明人： Christian GUTIERREZ

IPC分类号： A61F9/00 ,  A61B5/00 ,  G02C11/00 ,  G16H50/50 ,  G16H20/10 ,  A61B3/16

CPC分类号： A61F9/0017 ,  A61B5/4839 ,  A61B5/6821 ,  A61B5/7267 ,  G02C11/10 ,  A61B5/4857 ,  G16H50/50 ,  G16H20/10 ,  A61B3/16

摘要： Systems, eye-mountable devices, and methods that facilitate chronotherapeutic treatment of primary open-angle glaucoma are provided which enable therapeutic products to be delivered to the eye in a controlled manner only when desired. According to one embodiment, an eye-mountable device comprises a substrate having an eye-mounting surface for positioning on an eye of a patient, a sensor that obtains a plurality of measurements representative of a condition of the eye of the patient over a period of time, a therapeutic agent delivery assembly coupled, and a processor for executing a temporal model of a therapeutic agent delivery in communication with the sensor and the therapeutic agent delivery assembly. The processor receives the plurality of measurements and activates the therapeutic agent delivery assembly to administer a first amount of a drug to the eye of the patient based on the temporal model associated with the plurality of measurements.